Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1996-11-14
pubmed:abstractText
Listeria monocytogenes injected intravenously into mice is taken up in the liver, where hepatocytes serve as the principal site of intracellular replication. The factors effecting entry of L. monocytogenes into hepatic cells remain to be determined. Others have shown that the protein products of the inlAB (internalin) operon are required for maximum entry of L. monocytogenes into a number of cell lines in vitro. Likewise, we report here that expression of the inlAB operon was required for maximum uptake of L. monocytogenes by primary cultures of mouse hepatocytes. Uptake of an inlAB mutant strain of L. monocytogenes was approximately 10-fold less than that of the isogenic wild-type control. In contrast, inlAB expression was not a factor in (i) clearance of L. monocytogenes injected intravenously into mice and taken up in the liver, (ii) the distribution of L. monocytogenes among hepatocytes and nonparenchymal cells in the liver, or (iii) internalization of L. monocytogenes by hepatic cells in vivo. These latter findings suggest that infection of hepatic cells by L. monocytogenes in vivo does not require the protein products of the inlAB operon.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-14467923, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-1552639, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-1564405, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-1640177, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-1905979, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-1906842, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-1978036, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-2114361, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-2491841, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-2501445, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-2516599, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-4050195, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-6429043, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-6767792, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-723934, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-7558297, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-7565087, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-7591057, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-7681083, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-7729919, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-8127896, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-8335936, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-8359889, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-8476559, http://linkedlifedata.com/resource/pubmed/commentcorrection/8926058-8601315
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3983-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Expression of the inlAB operon by Listeria monocytogenes is not required for entry into hepatic cells in vivo.
pubmed:affiliation
Department of Medicine, University of Pittsburgh Medical Center, Pennsylvania, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.