pubmed-article:8925281 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:8925281 | lifeskim:mentions | umls-concept:C0026549 | lld:lifeskim |
pubmed-article:8925281 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
pubmed-article:8925281 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
pubmed-article:8925281 | lifeskim:mentions | umls-concept:C0087140 | lld:lifeskim |
pubmed-article:8925281 | lifeskim:mentions | umls-concept:C0555952 | lld:lifeskim |
pubmed-article:8925281 | lifeskim:mentions | umls-concept:C0228641 | lld:lifeskim |
pubmed-article:8925281 | lifeskim:mentions | umls-concept:C0012359 | lld:lifeskim |
pubmed-article:8925281 | lifeskim:mentions | umls-concept:C0040610 | lld:lifeskim |
pubmed-article:8925281 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:8925281 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
pubmed-article:8925281 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:8925281 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:8925281 | pubmed:issue | 1-2 | lld:pubmed |
pubmed-article:8925281 | pubmed:dateCreated | 1996-10-25 | lld:pubmed |
pubmed-article:8925281 | pubmed:abstractText | We have previously reported that repetitive, noxious colorectal distention (CRD) induces c-Fos in the lumbosacral spinal cord. This study examined the effects of the analgesics morphine and tramadol on c-Fos expression resulting from noxious CRD in the rat. Pre-treatment (30 min or 1 min, i.v.) with morphine (1.25 mg/kg-5.0 mg/kg) or tramadol (1 mg/kg-20 mg/kg) dose-dependently attenuated c-Fos expression to CRD in all areas of the L6-S1 spinal gray matter. The highest dose of morphine was equipotent to the highest dose of tramadol. Repetitive dosing (1/4 of the greatest dose every 30 min) was as effective as a single bolus dose for both drugs. The visceromotor response to CRD was dose-dependently attenuated by tramadol and was reversed by naloxone. However, the dose of tramadol that eliminated the visceromotor response (7% of control) reduced the c-Fos expression to 47% of control. These results demonstrate that these two analgesics attenuate immediate-early gene expression and the visceromotor response to a noxious visceral stimulus and suggest that complete attenuation of c-Fos expression is not necessary for these compounds to produce analgesia to a noxious visceral stimulus. | lld:pubmed |
pubmed-article:8925281 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8925281 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8925281 | pubmed:language | eng | lld:pubmed |
pubmed-article:8925281 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8925281 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:8925281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8925281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:8925281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8925281 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:8925281 | pubmed:month | Dec | lld:pubmed |
pubmed-article:8925281 | pubmed:issn | 0006-8993 | lld:pubmed |
pubmed-article:8925281 | pubmed:author | pubmed-author:GebhartG FGF | lld:pubmed |
pubmed-article:8925281 | pubmed:author | pubmed-author:TraumR ERE | lld:pubmed |
pubmed-article:8925281 | pubmed:author | pubmed-author:StittSS | lld:pubmed |
pubmed-article:8925281 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:8925281 | pubmed:day | 1 | lld:pubmed |
pubmed-article:8925281 | pubmed:volume | 701 | lld:pubmed |
pubmed-article:8925281 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:8925281 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:8925281 | pubmed:pagination | 175-82 | lld:pubmed |
pubmed-article:8925281 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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pubmed-article:8925281 | pubmed:meshHeading | pubmed-meshheading:8925281-... | lld:pubmed |
pubmed-article:8925281 | pubmed:year | 1995 | lld:pubmed |
pubmed-article:8925281 | pubmed:articleTitle | Attenuation of c-Fos expression in the rat lumbosacral spinal cord by morphine or tramadol following noxious colorectal distention. | lld:pubmed |
pubmed-article:8925281 | pubmed:affiliation | Department of Pharmacology, University of Iowa College of Medicine, Iowa City 52242, USA. | lld:pubmed |
pubmed-article:8925281 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:8925281 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:8925281 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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