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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1996-10-25
|
| pubmed:abstractText |
We have previously reported that repetitive, noxious colorectal distention (CRD) induces c-Fos in the lumbosacral spinal cord. This study examined the effects of the analgesics morphine and tramadol on c-Fos expression resulting from noxious CRD in the rat. Pre-treatment (30 min or 1 min, i.v.) with morphine (1.25 mg/kg-5.0 mg/kg) or tramadol (1 mg/kg-20 mg/kg) dose-dependently attenuated c-Fos expression to CRD in all areas of the L6-S1 spinal gray matter. The highest dose of morphine was equipotent to the highest dose of tramadol. Repetitive dosing (1/4 of the greatest dose every 30 min) was as effective as a single bolus dose for both drugs. The visceromotor response to CRD was dose-dependently attenuated by tramadol and was reversed by naloxone. However, the dose of tramadol that eliminated the visceromotor response (7% of control) reduced the c-Fos expression to 47% of control. These results demonstrate that these two analgesics attenuate immediate-early gene expression and the visceromotor response to a noxious visceral stimulus and suggest that complete attenuation of c-Fos expression is not necessary for these compounds to produce analgesia to a noxious visceral stimulus.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Analgesics, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine,
http://linkedlifedata.com/resource/pubmed/chemical/Naloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Tramadol
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
701
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
175-82
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8925281-Analgesics, Opioid,
pubmed-meshheading:8925281-Animals,
pubmed-meshheading:8925281-Behavior, Animal,
pubmed-meshheading:8925281-Colon,
pubmed-meshheading:8925281-Dose-Response Relationship, Drug,
pubmed-meshheading:8925281-Electromyography,
pubmed-meshheading:8925281-Gene Expression,
pubmed-meshheading:8925281-Genes, fos,
pubmed-meshheading:8925281-Male,
pubmed-meshheading:8925281-Morphine,
pubmed-meshheading:8925281-Naloxone,
pubmed-meshheading:8925281-Narcotic Antagonists,
pubmed-meshheading:8925281-Pain,
pubmed-meshheading:8925281-Physical Stimulation,
pubmed-meshheading:8925281-Rats,
pubmed-meshheading:8925281-Rats, Sprague-Dawley,
pubmed-meshheading:8925281-Rectum,
pubmed-meshheading:8925281-Spinal Cord,
pubmed-meshheading:8925281-Tramadol
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Attenuation of c-Fos expression in the rat lumbosacral spinal cord by morphine or tramadol following noxious colorectal distention.
|
| pubmed:affiliation |
Department of Pharmacology, University of Iowa College of Medicine, Iowa City 52242, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|