| pubmed-article:8923121 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8923121 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:8923121 | lifeskim:mentions | umls-concept:C0162758 | lld:lifeskim |
| pubmed-article:8923121 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:8923121 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8923121 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:8923121 | pubmed:dateCreated | 1997-3-19 | lld:pubmed |
| pubmed-article:8923121 | pubmed:abstractText | The serotonin (5-HT)-increasing action of 5-HT uptake or monoamine oxidase inhibitors is limited by a negative feedback at somatodendritic level. The excess 5-HT produced by these antidepressant drugs in the interstitial space of the midbrain raphe activates somatodendritic 5-HT1A autoreceptors, thereby attenuating terminal 5-HT release. This effect is maximal in forebrain areas innervated by the dorsal raphe nucleus and can be prevented by the administration of non-selective [(-)pindolol, (-)tertatolol] and selective (WAY-100635) 5-HT1A antagonists. In keeping with these observations, the combined administration of selective serotonin reuptake inhibitors (SSRIs) and 5-HT1A antagonists increase the cortical and striatal extracellular 5-HT concentration more than the former alone. Also, concurrent inhibition of the 5-HT and noradrenaline transporters with 20 mg/kg imipramine increases cortical extracellular 5-HT concentration more than SSRI doses which maximally block the 5-HT transporter. Moreover, the effects of fluoxetine on frontal cortex 5-HT are potentiated by a dose of desipramine that does not modify extracellular 5-HT by itself. Given the relevance of increased serotonergic transmission in the treatment of depression, these experimental data indicate that dual-action antidepressant treatments may be more effective than those which selectively inhibit the 5-HT transporter. | lld:pubmed |
| pubmed-article:8923121 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8923121 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8923121 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8923121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8923121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8923121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8923121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8923121 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8923121 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8923121 | pubmed:issn | 0268-1315 | lld:pubmed |
| pubmed-article:8923121 | pubmed:author | pubmed-author:RomeroLL | lld:pubmed |
| pubmed-article:8923121 | pubmed:author | pubmed-author:ArtigasFF | lld:pubmed |
| pubmed-article:8923121 | pubmed:author | pubmed-author:BeiAA | lld:pubmed |
| pubmed-article:8923121 | pubmed:author | pubmed-author:CasanovasJ... | lld:pubmed |
| pubmed-article:8923121 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8923121 | pubmed:volume | 11 Suppl 4 | lld:pubmed |
| pubmed-article:8923121 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8923121 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8923121 | pubmed:pagination | 1-8 | lld:pubmed |
| pubmed-article:8923121 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8923121 | pubmed:meshHeading | pubmed-meshheading:8923121-... | lld:pubmed |
| pubmed-article:8923121 | pubmed:meshHeading | pubmed-meshheading:8923121-... | lld:pubmed |
| pubmed-article:8923121 | pubmed:meshHeading | pubmed-meshheading:8923121-... | lld:pubmed |
| pubmed-article:8923121 | pubmed:meshHeading | pubmed-meshheading:8923121-... | lld:pubmed |
| pubmed-article:8923121 | pubmed:meshHeading | pubmed-meshheading:8923121-... | lld:pubmed |
| pubmed-article:8923121 | pubmed:meshHeading | pubmed-meshheading:8923121-... | lld:pubmed |
| pubmed-article:8923121 | pubmed:meshHeading | pubmed-meshheading:8923121-... | lld:pubmed |
| pubmed-article:8923121 | pubmed:meshHeading | pubmed-meshheading:8923121-... | lld:pubmed |
| pubmed-article:8923121 | pubmed:meshHeading | pubmed-meshheading:8923121-... | lld:pubmed |
| pubmed-article:8923121 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8923121 | pubmed:articleTitle | Two actions are better than one: avoiding self-inhibition of serotonergic neurones enhances the effects of serotonin uptake inhibitors. | lld:pubmed |
| pubmed-article:8923121 | pubmed:affiliation | Department of Neurochemistry, Instituto de Investigaciones Biomédicas de Barcelona, CSIC. | lld:pubmed |
| pubmed-article:8923121 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8923121 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8923121 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:8923121 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
