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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1997-3-10
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pubmed:abstractText |
1. We studied whether the stimulation of 5-HT1A receptors by 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a specific 5-HT1A receptor agonist, reduced electroencephalographic (EEG) seizures induced by intrahippocampal injection of 0.04 microgram in 0.5 microliter of the glutamate analogue kainic acid in freely-moving rats. 2. Pretreatment with 8-OH-DPAT 15 min earlier at the same site as kainic acid injection, caused a dose-dependent decrease of kainic acid-induced seizure activity. One and 10 micrograms significantly reduced the total time spent in seizures by 72% on average and the total number of seizures by 58% (P < 0.01) and 43% (P < 0.05) respectively. The latency to onset of the first seizure was increased 2.8 times (P < 0.01) only after 1 microgram 8-OH-DPAT; 0.1 microgram was ineffective on all seizure parameters. 3. Systemic administration of 25, 100 and 1000 micrograms kg-1 8-OH-DPAT significantly reduced the total number of seizures and the total time in seizures induced by intrahippocampal kainic acid by 52% and 74% on average. The latency to onset of the first seizure was delayed 1.8 times by 100 and 1000 micrograms kg-1 (P < 0.05). 4. The anticonvulsant action of 8-OH-DPAT given intrahippocampally or systemically was significantly blocked by 5 micrograms, but not 1 microgram WAY 100635, a selective 5-HT1A receptor antagonist, administered in the hippocampus before the agonist. 5. These results indicate that postsynaptic 5-HT1A receptors in the hippocampus mediate the anticonvulsant action of 8-OH-DPAT and that their stimulation has an inhibitory role in the generation of limbic seizures.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-1327268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-1385752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-1407393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-1467958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-1515949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-1531498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-1545909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-1792002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-1830135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-2163714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-2325849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-2402343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-2471114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-2580072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-2843792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-2859548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-2862329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-2932661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-2945004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-2965025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-317724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-3925335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-4257017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-4822045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-565370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-6193970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-6433201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-6460101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-6842403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-7177385,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-7477995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-7498302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-7712172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-8137162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-8149989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-8255539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-8264964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8922726-8574685
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
813-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8922726-8-Hydroxy-2-(di-n-propylamino)tetralin,
pubmed-meshheading:8922726-Animals,
pubmed-meshheading:8922726-Anticonvulsants,
pubmed-meshheading:8922726-Electroencephalography,
pubmed-meshheading:8922726-Hippocampus,
pubmed-meshheading:8922726-Kainic Acid,
pubmed-meshheading:8922726-Male,
pubmed-meshheading:8922726-Piperazines,
pubmed-meshheading:8922726-Pyridines,
pubmed-meshheading:8922726-Rats,
pubmed-meshheading:8922726-Rats, Sprague-Dawley,
pubmed-meshheading:8922726-Seizures,
pubmed-meshheading:8922726-Serotonin Antagonists,
pubmed-meshheading:8922726-Serotonin Receptor Agonists
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pubmed:year |
1996
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pubmed:articleTitle |
Stimulation of 5-HT1A receptors in the dorsal hippocampus and inhibition of limbic seizures induced by kainic acid in rats.
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pubmed:affiliation |
Laboratory of Neuropharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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