Linked Life Data

8922060

Source:http://linkedlifedata.com/resource/pubmed/id/8922060

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-3-12
pubmed:abstractText
The effect of the cytokine, colony stimulating factor-1 (CSF-1), on neuronal survival in cerebral cortex ischemic lesion was determined. Ischemic lesions were made in C3H/HeJ mice by disrupting blood vessels that penetrate the cerebral cortex from the pial-vascular plexus. Recombinant human colony stimulating factor 1 (rhCSF-1) was delivered in chitosan microcapsules that were either implanted intraperitoneally 2 weeks before surgery or at the site of the lesion at the time of surgery. Neuronal survival was twofold greater and the size of the infarct was considerably smaller in animals that received rhCSF-1-containing microcapsules. There was no significant difference whether the microcapsules were implanted intraperitoneally or at the site of the lesion. We found that CSF-1 receptor (c-fms) was upregulated in neurons at the site of the lesion and we propose that neuron rescue in ischemic damage is potentiated by CSF-1 signaling through CSF-1 receptor in the neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0001-6322
pubmed:author
pubmed:issnType
Print
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
479-86
pubmed:dateRevised
2007-11-9
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Colony stimulating factor-1 potentiates neuronal survival in cerebral cortex ischemic lesion.
pubmed:affiliation
Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't