Linked Life Data

8920664

Source:http://linkedlifedata.com/resource/pubmed/id/8920664

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-12-31
pubmed:abstractText
It is known that transformation of normal cells to cancer cells is caused by the accumulation of successive mutations in oncogenes and/or tumor suppressor genes. Since four DNA mismatch repair genes (hMSH2, hMLH1, hPMS1 and hPMS2) have been identified as the cause of hereditary nonpolyposis colorectal cancer (HNPCC), the role of defective mismatch repair system in the development of sporadic cancers with microsatellite instability has also been discussed. Defects in mismatch repair genes would contribute to mutations in genes, including oncogenes and tumor suppressor genes, at an increased rate. Furthermore, recent investigations suggested that this mechanism was also involved in the development of multiple primary cancers as well.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1002-7
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
[Disruption of mismatch repair system in human cancers].
pubmed:affiliation
Department of Molecular Pathology, Tohoku University School of Medicine.
pubmed:publicationType
Journal Article, English Abstract, Review