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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1996-12-12
|
| pubmed:abstractText |
Protective immunity against infection with Mycobacterium tuberculosis is imparted by T cells rather than antibodies, but B cells can play a role as antigen-presenting cells and in granuloma formation. We re-evaluated the role of B cells in the course of tuberculous infection in mu-chain knock-out (Ig-) mice. Surprisingly, the organs of M. tuberculosis-infected Ig- mice were found to have three- to eight-fold elevated counts of viable bacilli compared with normal littermates at 3-6 weeks post-infection. Splenic interferon-gamma responses to whole antigen were unimpaired, whilst proliferation to certain mycobacterial peptides was found to be diminished. However, bacille Calmette-Guérin (BCG) vaccination significantly reduced the infection in Ig- mice. The mechanisms by which B cells can influence primary tuberculous infection need further study.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0009-9104
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
106
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
312-6
|
| pubmed:dateRevised |
2008-11-20
|
| pubmed:meshHeading |
pubmed-meshheading:8918578-Animals,
pubmed-meshheading:8918578-B-Lymphocytes,
pubmed-meshheading:8918578-BCG Vaccine,
pubmed-meshheading:8918578-Colony Count, Microbial,
pubmed-meshheading:8918578-Cytokines,
pubmed-meshheading:8918578-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:8918578-Female,
pubmed-meshheading:8918578-Genes, Immunoglobulin,
pubmed-meshheading:8918578-Immunoglobulin mu-Chains,
pubmed-meshheading:8918578-Immunologic Deficiency Syndromes,
pubmed-meshheading:8918578-Liver,
pubmed-meshheading:8918578-Lung,
pubmed-meshheading:8918578-Male,
pubmed-meshheading:8918578-Mice,
pubmed-meshheading:8918578-Mice, Knockout,
pubmed-meshheading:8918578-Mycobacterium tuberculosis,
pubmed-meshheading:8918578-Spleen,
pubmed-meshheading:8918578-T-Lymphocytes,
pubmed-meshheading:8918578-Tuberculosis,
pubmed-meshheading:8918578-Vaccination
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Increase of tuberculous infection in the organs of B cell-deficient mice.
|
| pubmed:affiliation |
MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK.
|
| pubmed:publicationType |
Journal Article
|