Linked Life Data

8918241

Source:http://linkedlifedata.com/resource/pubmed/id/8918241

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1997-1-7
pubmed:databankReference
pubmed:abstractText
Removal of introns from pre-messenger RNA (pre-mRNA) requires small nuclear RNAs (snRNAs) packaged into stable small ribonucleoprotein particles (snRNP). These snRNPs contain specific and common proteins also called Sm proteins. Correct assembly of the snRNAs with the common proteins is an essential step for the biogenesis of snRNP particles. We have identified a new Saccharomyces serevisiae gene, SME1 whose product shows 45% identity with the E core protein of human snRNP. The Sme1p contains the evolutionary conserved residues found in all Sm proteins. Combining genetic and biochemical experiments, we show that SME1 is an essential gene required for pre-mRNA splicing, cap modification and U1, U2, U4 and U5 snRNA stability. We show also that the human E core protein complements a yeast SME1 disruption demonstrating the functional equivalence of Sme1p and the human E core protein.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0378-1119
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
176
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
111-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:8918241-Amino Acid Sequence, pubmed-meshheading:8918241-Base Sequence, pubmed-meshheading:8918241-Cell Cycle Proteins, pubmed-meshheading:8918241-DNA, Fungal, pubmed-meshheading:8918241-Fungal Proteins, pubmed-meshheading:8918241-Humans, pubmed-meshheading:8918241-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:8918241-Molecular Sequence Data, pubmed-meshheading:8918241-Protein Kinases, pubmed-meshheading:8918241-Protein-Serine-Threonine Kinases, pubmed-meshheading:8918241-RNA Precursors, pubmed-meshheading:8918241-RNA Splicing, pubmed-meshheading:8918241-Ribonucleoproteins, Small Nuclear, pubmed-meshheading:8918241-Saccharomyces cerevisiae, pubmed-meshheading:8918241-Saccharomyces cerevisiae Proteins, pubmed-meshheading:8918241-Sequence Homology, Amino Acid, pubmed-meshheading:8918241-Spliceosomes
pubmed:year
1996
pubmed:articleTitle
The yeast SME1 gene encodes the homologue of the human E core protein.
pubmed:affiliation
UPR 9005, Mécanismes Moléculaires de la Division Cellulaire et du Développement, IBMC, Strasbourg, France. bordonne@lynch.u-strasbg.fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't