Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
1996-12-30
pubmed:databankReference
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39209, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39210, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39211, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39212, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39213, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39214, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39215, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39216, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39217, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39218, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39219, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39220, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39221, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39222, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39223, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39224, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U39225
pubmed:abstractText
Vesicular stomatitis New Jersey virus (VSV-NJ) is a rhabdovirus that causes economically important disease in cattle and other domestic animals in endemic areas from southeastern United States to northern South America. Its negatively stranded RNA genome is capable of undergoing rapid evolution, which allows phylogenetic analysis and molecular epidemiology studies to be performed. Previous epidemiological studies in Costa Rica showed the existence of at least two distinct ecological zones of high VSV-NJ activity, one located in the highlands (premontane tropical moist forest) and the other in the lowlands (tropical dry forest). We wanted to test the hypothesis that the viruses circulating in these ecological zones were genetically distinct. For this purpose, we sequenced the hypervariable region of the phosphoprotein gene for 50 VSV-NJ isolates from these areas. Phylogenetic analysis showed that viruses from each ecological zone had distinct genotypes. These genotypes were maintained in each area for periods of up to 8 years. This evolutionary pattern of VSV-NJ suggests an adaptation to ecological factors that could exert selective pressure on the virus. As previous data indicated an absence of virus adaptation to factors related to the bovine host (including immunological pressure), it appears that VSV genetic divergence represents positive selection to adapt to specific vectors and/or reservoirs at each ecological zone.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-1322991, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-1579108, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-1693802, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-1840695, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-1971158, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-2033662, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-2156464, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-2159527, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-2160198, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-2168974, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-2536983, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-2848126, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-2922271, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-3029973, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-3034056, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-4309413, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-4335268, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-4781535, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-7446826, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-7474092, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-7485685, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-7815407, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-8197141, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-8248125, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-8347076, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-8380072, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-8388514, http://linkedlifedata.com/resource/pubmed/commentcorrection/8917539-8396584
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13030-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:8917539-Animals, pubmed-meshheading:8917539-Animals, Domestic, pubmed-meshheading:8917539-Cattle, pubmed-meshheading:8917539-Cattle Diseases, pubmed-meshheading:8917539-Central America, pubmed-meshheading:8917539-Climate, pubmed-meshheading:8917539-Culicidae, pubmed-meshheading:8917539-Ecology, pubmed-meshheading:8917539-Evolution, Molecular, pubmed-meshheading:8917539-Genome, Viral, pubmed-meshheading:8917539-Geography, pubmed-meshheading:8917539-Mexico, pubmed-meshheading:8917539-Molecular Sequence Data, pubmed-meshheading:8917539-New Jersey, pubmed-meshheading:8917539-Phylogeny, pubmed-meshheading:8917539-Rhabdoviridae Infections, pubmed-meshheading:8917539-Swine, pubmed-meshheading:8917539-Time, pubmed-meshheading:8917539-United States, pubmed-meshheading:8917539-Vesiculovirus
pubmed:year
1996
pubmed:articleTitle
Ecological factors rather than temporal factors dominate the evolution of vesicular stomatitis virus.
pubmed:affiliation
Tropical Disease Research Program, School of Veterinary Medicine, Universidad Nacional, Heredia, Costa Rica.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't