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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
1996-12-30
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pubmed:abstractText |
The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and desensitization of G protein-coupled receptors. We have cloned and disrupted the beta ARK1 gene in mice by homologous recombination. No homozygote beta ARK1-/- embryos survive beyond gestational day 15.5. Prior to gestational day 15.5, beta ARK1-/- embryos display pronounced hypoplasia of the ventricular myocardium essentially identical to the "thin myocardium syndrome" observed upon gene inactivation of several transcription factors (RXR alpha, N-myc, TEF-1, WT-1). Lethality in beta ARK1-/- embryos is likely due to heart failure as they exhibit a > 70% decrease in cardiac ejection fraction determined by direct in utero intravital microscopy. These results along with the virtual absence of endogenous GRK activity in beta ARK1-/- embryos demonstrate that beta ARK1 appears to be the predominant GRK in early embryogenesis and that it plays a fundamental role in cardiac development.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-1331675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-1339451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-1349018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-1459450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-1832775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-1835945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-2552582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-2682666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-2712003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-3291115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-5638471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-7618084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-7638202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-7638203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-7671848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-7761854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-7824934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-7923367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-7926783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-8146176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-8207020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-8226899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-8287798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-8293560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-8316831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-8395349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-8466192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-8553074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8917529-8593692
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
12974-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8917529-Animals,
pubmed-meshheading:8917529-Chimera,
pubmed-meshheading:8917529-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:8917529-DNA Primers,
pubmed-meshheading:8917529-Embryonic and Fetal Development,
pubmed-meshheading:8917529-Exons,
pubmed-meshheading:8917529-Female,
pubmed-meshheading:8917529-Fetal Death,
pubmed-meshheading:8917529-Fetal Heart,
pubmed-meshheading:8917529-Heart Defects, Congenital,
pubmed-meshheading:8917529-Homozygote,
pubmed-meshheading:8917529-Mice,
pubmed-meshheading:8917529-Mice, Transgenic,
pubmed-meshheading:8917529-Myocardium,
pubmed-meshheading:8917529-Polymerase Chain Reaction,
pubmed-meshheading:8917529-Pregnancy,
pubmed-meshheading:8917529-Recombination, Genetic,
pubmed-meshheading:8917529-beta-Adrenergic Receptor Kinases
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pubmed:year |
1996
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pubmed:articleTitle |
Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.
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pubmed:affiliation |
Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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