Linked Life Data

8917407

Source:http://linkedlifedata.com/resource/pubmed/id/8917407

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5A
pubmed:dateCreated
1996-12-18
pubmed:abstractText
We investigated the effects of hyaluronic acid (HA) on the invasiveness of three human glioma cell lines (A172, T98G and U251) and their secretion of matrix metalloproteinases (MMPs), plasminogen activators (PAs), and hyaluronidase. The invasion of all three glioma cell lines was enhanced by the impregnation of Matrigel with HA in an in vitro invasion assay using 12 microns porosity polycarbonate filter transwells. The secretion of MMPs and PAs was not influenced by the presence of HA. Hyaluronidase activity was not detected in the culture media of any glioma cell line. HA also enhanced the motility of A172 and U251 glioma cells, but did not influence the motility of T98G glioma cells. The adhesion and spreading of all glioma cell lines were inhibited on HA-coated plates. HA, however, did not influence the proliferation of any of the glioma cell line. These results suggest that the presence of HA contributes to glioma cell invasion, which involves the stimulation of detachment and motility of glioma cells and the maintenance of proteinase secretion by glioma cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2917-22
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:articleTitle
Hyaluronic acid facilitates glioma cell invasion in vitro.
pubmed:affiliation
Department of Neurosurgery, Fukui Medical School, Japan.
pubmed:publicationType
Journal Article