Linked Life Data

8916505

Source:http://linkedlifedata.com/resource/pubmed/id/8916505

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1996-12-6
pubmed:abstractText
The goals of this study of adults asymptomatic for coronary artery disease (CAD) were to examine the relations between established CAD risk factors and quantity of coronary artery calcification (CAC) in three arterial locations using generalized linear mixed models and to estimate the variability in quantity of CAC explained by established CAD risk factors and the variability due to noise or artifact in the measure. The community-based sample included 740 asymptomatic adults (378 women) aged 20-59 years without hypertension or diabetes. Participants were recruited from Rochester, Minnesota, between 1990 and 1994. Quantity of CAC in three arterial locations was detected noninvasively by electron beam computed tomography. Sex, arterial location, age, body size, blood pressure, lipid metabolism, and smoking were significantly (p < 0.05) associated with quantity of CAC. Age was more strongly associated with quantity of CAC in the left than in the right coronary or circumflex arterial locations (p < 0.005). In each sex, risk factors together explained less than 40% of the variability in quantity of CAC. Noise or artifact in the measure accounted for only a small proportion of unexplained variability. Future studies of new risk factors for artery-specific quantity of CAC and its progression could provide additional etiologic insights into the atherosclerotic process.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-9262
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
144
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
943-53
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Potential of quantity of coronary artery calcification to identify new risk factors for asymptomatic atherosclerosis.
pubmed:affiliation
Department of Epidemiology, University of Michigan, Ann Arbor 48109, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't