Linked Life Data

8915190

Source:http://linkedlifedata.com/resource/pubmed/id/8915190

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-12-4
pubmed:abstractText
Eicosanoids are important mediators of both physiological and pathophysiological responses of the microcirculation. These biologically active lipid mediators can be produced locally by the cellular elements within the microvasculature (endothelium, pericytes, smooth muscle cells) as well as interstitial cells (e.g. fibroblasts, mast cells) and by various cells in the vascular compartment (e.g. leukocytes, platelets). Transcellular metabolism of intermediates produced by one cell type in close contact with another also has the potential to generate potent metabolites. This review integrates some of the older literature with recent developments in eicosanoid synthesis and release, the molecular advances in the enzymology and receptor specificity of the eicosanoids and the regulation by autocoids and inflammatory mediators. The potential roles of eicosanoids in regulation of local blood flow, vascular reactivity, angiogenesis and leukocyte adhesion and transmigration are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0008-6363
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
720-32
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Physiological and pathophysiological roles of eicosanoids in the microcirculation.
pubmed:affiliation
Institute for Bone and Joint Disease and Cancer, Bayer Corporation, West Haven, CT 06516, USA.
pubmed:publicationType
Journal Article, Review