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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1997-5-6
|
| pubmed:abstractText |
This paper reports on some pharmacological and biological properties of 22-mer antisense oligodeoxynucleotides which contain an L-deoxyribonucleoside at each terminus. Compared with natural compounds, of which they retain the DNA hybridizing ability and the cell uptake mechanism, the L-22-mers exhibited an increased resistance to phosphodiesterase degradation, an apparent higher intracellular concentration and a longer intracellular half life. Antiviral activity was not prominent.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1121-7138
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
273-84
|
| pubmed:dateRevised |
2011-2-25
|
| pubmed:meshHeading |
pubmed-meshheading:8914127-Animals,
pubmed-meshheading:8914127-Antigens, Polyomavirus Transforming,
pubmed-meshheading:8914127-Cells, Cultured,
pubmed-meshheading:8914127-Cercopithecus aethiops,
pubmed-meshheading:8914127-Half-Life,
pubmed-meshheading:8914127-Humans,
pubmed-meshheading:8914127-Nucleic Acid Denaturation,
pubmed-meshheading:8914127-Oligonucleotides, Antisense,
pubmed-meshheading:8914127-Phosphoric Diester Hydrolases,
pubmed-meshheading:8914127-Simian virus 40,
pubmed-meshheading:8914127-T-Lymphocytes
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
3'-5' L-capped-antisense oligodeoxynucleotides targeted at the SV40 T-antigen gene: pharmacological and biological properties.
|
| pubmed:affiliation |
Institute of Microbiology, University of Padova, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|