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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1997-3-3
|
| pubmed:abstractText |
Quantification of hepatitis C virus RNA in liver tissue is likely to be useful in the study of the natural history, pathogenesis, progression and treatment of hepatitis C virus-associated liver disease. Quantitative measurements of hepatitis C virus RNA in liver biopsy samples using the branched DNA (bDNA) signal amplification assay were carried out. The aims of this study were threefold: first, to assess the level of hepatitis C virus RNA in biopsy samples from the right and left lobes of the liver; second, to evaluate the correlation between hepatitis C virus RNA levels in serum and liver; and third, to investigate the relationship between serum and liver hepatitis C virus RNA levels and the severity of hepatic histology in non-cirrhotic patients with chronic hepatitis C. There was a strong correlation (r = 0.92, P < 0.01) between hepatitis C virus RNA levels in the right and left lobes of the liver as well as a strong correlation between hepatitis C virus RNA levels in liver and serum (r = 0.82, P < 0.01). However, there was no significant correlation between the severity of hepatic histology and levels of hepatitis C virus RNA in serum and liver among patients with chronic active hepatitis classified according to Knodell's hepatic activity index (KI). Our results indicate that hepatitis C virus RNA quantification from a single liver biopsy is representative of both lobes in patients with chronic hepatitis, and suggest that serum hepatitis C virus RNA levels are a meaningful reflection of hepatitis C virus RNA levels in the liver.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1352-0504
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
239-46
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8914003-Adult,
pubmed-meshheading:8914003-Aged,
pubmed-meshheading:8914003-Biopsy,
pubmed-meshheading:8914003-Female,
pubmed-meshheading:8914003-Hepacivirus,
pubmed-meshheading:8914003-Hepatitis C,
pubmed-meshheading:8914003-Humans,
pubmed-meshheading:8914003-Liver,
pubmed-meshheading:8914003-Male,
pubmed-meshheading:8914003-Middle Aged,
pubmed-meshheading:8914003-Nucleic Acid Hybridization,
pubmed-meshheading:8914003-Polymerase Chain Reaction,
pubmed-meshheading:8914003-RNA, Viral,
pubmed-meshheading:8914003-Severity of Illness Index,
pubmed-meshheading:8914003-Viral Load
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Hepatitis C virus RNA quantification in right and left lobes of the liver in patients with chronic hepatitis C.
|
| pubmed:affiliation |
Division of Hepatology, University of Miami School of Medicine, FL, USA.
|
| pubmed:publicationType |
Journal Article
|