Linked Life Data

8912178

Source:http://linkedlifedata.com/resource/pubmed/id/8912178

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1997-2-14
pubmed:abstractText
T cell interaction with antigenic peptides leads to signal transduction and activation events in the effector cells. Recent studies of T cell responses to subtle variants of antigenic peptides can lead to alterations in the activation state of T cells. A variety of physiological roles for altered peptide ligands have recently been postulated, and their potential therapeutic applications have generated considerable interest. This review summarizes progress made in understanding the T cell signal transduction pathways and the nature of T cell responses to altered peptide ligands. Our recent observation of a self peptide as a partial agonist for a cytotoxic T cell clone directed to a foreign antigen suggests that naturally occurring altered peptide ligands may be important in regulating T cell mediated immune response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0946-2716
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
573-82
pubmed:dateRevised
2011-7-8
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Partial activation of foreign antigen specific T lymphocytes by a self peptide: possible roles of altered peptide ligands in regulating T lymphocyte mediated immune response.
pubmed:affiliation
Beirne B. Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
pubmed:publicationType
Journal Article, Review