Linked Life Data

89119

Source:http://linkedlifedata.com/resource/pubmed/id/89119

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1979-10-26
pubmed:abstractText
Circulating antibodies against certain nuclear acidic protein antigens have been shown to have diagnostic and prognostic importance in connective tissue disease. We describe a new precipitin system found in the sera of patients with systemic lupus erythematosus. The antigen, called MA, was prepared from calf thymus nuclei, and was shown to be distinct from other nuclear acidic protein antigens by physicochemical and immunologic techniques. MA antibodies were detected in the serum of 12 of 66 lupus patients and in none of 554 sera from normal controls or patients with other rheumatic diseases. Lupus patients having MA antibodies had more severe disease than did lupus patients with Sm or native DNA antibodies, manifested by recalcitrant skin rashes and a significantly greater incidence of hypocomplementemia, serious renal disease, hypertension, hepatosplenomegaly, lymphadenopathy, and neurological disease (P values range from 0.025 to 0.005). The presence of circulating MA antigen was demonstrated in three lupus patients immediately before a flare of nephritis. These data suggest that MA is a nuclear acidic protein antigen that may identify a subset of lupus patients with very severe disease. The presence of the antigen in the circulation before clinical flares suggests a possible biologic role for the MA system in an immune complex nephritis.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/89119-1084750, http://linkedlifedata.com/resource/pubmed/commentcorrection/89119-318657, http://linkedlifedata.com/resource/pubmed/commentcorrection/89119-324482, http://linkedlifedata.com/resource/pubmed/commentcorrection/89119-4179557, http://linkedlifedata.com/resource/pubmed/commentcorrection/89119-4184826, http://linkedlifedata.com/resource/pubmed/commentcorrection/89119-4621694, http://linkedlifedata.com/resource/pubmed/commentcorrection/89119-4959277, http://linkedlifedata.com/resource/pubmed/commentcorrection/89119-4960935, http://linkedlifedata.com/resource/pubmed/commentcorrection/89119-4964289, http://linkedlifedata.com/resource/pubmed/commentcorrection/89119-64473, http://linkedlifedata.com/resource/pubmed/commentcorrection/89119-804494
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
820-3
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Characterization of a distinct nuclear acidic protein antigen (MA) and clinical findings in systemic lupus erythematosus patients with MA antibodies.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.