Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
|
pubmed:dateCreated |
1997-2-13
|
pubmed:abstractText |
Evidence from several sources suggests that important interactions occur between platelets and low-density lipoproteins. This study was undertaken to find out if diet-induced hypercholesterolaemia affects the growth factor content in circulating platelets. Minipigs were fed either normal diet supplemented with 2% cholesterol (n = 12) or normal diet alone (n = 12). After 4 months, mean platelet volume was significantly lower (P < 0.05) and monocyte count was significantly higher (P < 0.05) in the cholesterol group. Serum and intraplatelet levels of platelet-derived growth factor (BB homodimer) and transforming growth factor beta 1 were statistically unchanged after diet. Hypercholesterolaemia did not affect the proliferative effect of either serum or platelet lysates on porcine vascular smooth muscle cells and Swiss-3T3 cells in culture. A significant positive correlation between Swiss-3T3 and smooth muscle cell proliferation was present in both groups. These results suggest that the atherosclerosis-promoting effect of hypercholesterolaemia cannot be explained by its direct effect on smooth muscle cell proliferation or by changes in serum or intraplatelet concentrations of growth factors.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0014-2972
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
26
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
929-35
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8911868-3T3 Cells,
pubmed-meshheading:8911868-Animals,
pubmed-meshheading:8911868-Blood Cell Count,
pubmed-meshheading:8911868-Blood Platelets,
pubmed-meshheading:8911868-Hypercholesterolemia,
pubmed-meshheading:8911868-Male,
pubmed-meshheading:8911868-Mice,
pubmed-meshheading:8911868-Platelet-Derived Growth Factor,
pubmed-meshheading:8911868-Swine,
pubmed-meshheading:8911868-Swine, Miniature,
pubmed-meshheading:8911868-Transforming Growth Factor beta
|
pubmed:year |
1996
|
pubmed:articleTitle |
Effect of hypercholesterolaemia on platelet growth factors.
|
pubmed:affiliation |
Department of Cardiology, University Clinic and School of Medicine, Pamplona, Spain.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|