Linked Life Data

8910255

Source:http://linkedlifedata.com/resource/pubmed/id/8910255

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-2-28
pubmed:abstractText
The ontogeny of graft versus host (GvH) reactivity of thymocytes and splenocytes was tested in C57BL female mice from the day of birth up to the age of 24 months. In comparison with virgin mice, the effect of a different number of pregnancies, with or without lactation, on the GvH reactivity was examined in middle-aged and aging female mice. The most striking results were obtained with suckling, aging 18-month-old multiparas. After three or more pregnancies with lactation--regardless of the number of pregnancies without suckling--the weight and cell count of the thymus and GvH reactivities on both thymocytes and splenocytes were significantly increased and were comparable with those of middle-aged, 12-month-old virgins. The present results indicate that physiological lactation periods are responsible for the long-lasting, immunoenhancing effect of multiparity, and that the maternal thymus is involved in the mechanism of this phenomenon. A possible role of prolactin rejuvenation of the thymus in suckling multiparas is suggested.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0047-6374
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
The effect of multiparity and lactation periods on the graft versus host reactivity of thymocytes and splenocytes from aging C57BL mice.
pubmed:affiliation
Department of Immunobiology, Polish Academy of Sciences, Kraków, Poland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't