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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1997-2-12
|
| pubmed:abstractText |
The human X chromosome is associated with a large number of disease phenotypes, principally because of its unique mode of inheritance that tends to reveal all recessive disorders in males. With the longer term goal of identifying and characterizing most of these genes, we have adopted a chromosome-wide strategy to establish a YAC contig map. We have performed > 3250 inter Alu-PCR product hybridizations to identify overlaps between YAC clones. Positional information associated with many of these YAC clones has been derived from our Reference Library Database and a variety of other public sources. We have constructed a YAC contig map of the X chromosome covering 125 Mb of DNA in 25 contigs and containing 906 YAC clones. These contigs have been verified extensively by FISH and by gel and hybridization fingerprinting techniques. This independently derived map exceeds the coverage of recently reported X chromosome maps built as part of whole-genome YAC maps.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1088-9051
|
| pubmed:author |
pubmed-author:BentleyD RDR,
pubmed-author:CoffeyA JAJ,
pubmed-author:DAYM FMF,
pubmed-author:GraeserDD,
pubmed-author:GregoryS GSG,
pubmed-author:GrigorievAA,
pubmed-author:HollowayEE,
pubmed-author:HumphrayS JSJ,
pubmed-author:KnightsC JCJ,
pubmed-author:KumlienJJ,
pubmed-author:LabellePP,
pubmed-author:LamVV,
pubmed-author:LehrachHH,
pubmed-author:LiKK,
pubmed-author:MarshSS,
pubmed-author:MisfudJJ,
pubmed-author:MonacoA PAP,
pubmed-author:MottRR,
pubmed-author:PlayfordMM,
pubmed-author:PoustkaAA,
pubmed-author:RappoldGG,
pubmed-author:Roest CrolliusHH,
pubmed-author:RossM TMT,
pubmed-author:SeeC GCG,
pubmed-author:TodaHH,
pubmed-author:VatchevaRR,
pubmed-author:ZehetnerGG
|
| pubmed:issnType |
Print
|
| pubmed:volume |
6
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
943-55
|
| pubmed:dateRevised |
2008-4-3
|
| pubmed:meshHeading |
pubmed-meshheading:8908513-Chromosome Mapping,
pubmed-meshheading:8908513-Chromosomes, Artificial, Yeast,
pubmed-meshheading:8908513-Cloning, Molecular,
pubmed-meshheading:8908513-DNA Fingerprinting,
pubmed-meshheading:8908513-Humans,
pubmed-meshheading:8908513-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8908513-Male,
pubmed-meshheading:8908513-X Chromosome
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
An integrated YAC map of the human X chromosome.
|
| pubmed:affiliation |
Max-Planck-Institut für Molekulare Genetik, Berlin, Germany. roest@mpimg-berlin-dahlem.mpg.de
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|