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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1997-2-18
|
| pubmed:abstractText |
The frequency of insulin-dependent diabetes mellitus in the Turkish adult-onset diabetic population has not been assessed previously. In the present study, we retrospectively evaluated the medical records of 801 Turkish patients with adult-onset (> or = 30 years) diabetes to determine the frequency of cases diagnosed as insulin-dependent diabetes. Fifty-two (6.5%) patients met our criteria of adult-onset insulin-dependent diabetes mellitus. At disease onset, 20 patients presented with ketoacidosis (38.5%), while 32 patients (61.5%) were non-ketotic. In the insulin-dependent diabetic group, islet cell antibodies were positive in 10 out of 16 (62.5%) patients studied. In contrast, none of the 16 patients had positive reactions with respect to insulin autoantibodies. Twelve out of 20 patients (60%) had glucagon-stimulated C-peptide levels above 0.6 nmol/l, suggesting a sufficient insulin secretory reserve. In view of these observations, we conclude that insulin-dependent diabetes mellitus is not rare among patients with adult-onset diabetes in the Turkish population. In a majority of cases, the disease onset is non-ketotic. Beta-cell function is relatively preserved, and insulin autoantibodies do not develop at diagnosis. In contrast, islet cell antibodies are frequently present at the onset of clinical insulin-dependent diabetes, possibly indicating continuing beta-cell destruction.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/C-Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/islet cell antibody
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0940-5429
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
216-9
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8904928-Adult,
pubmed-meshheading:8904928-Age Factors,
pubmed-meshheading:8904928-Age of Onset,
pubmed-meshheading:8904928-Autoantibodies,
pubmed-meshheading:8904928-Blood Glucose,
pubmed-meshheading:8904928-C-Peptide,
pubmed-meshheading:8904928-Diabetes Mellitus, Type 1,
pubmed-meshheading:8904928-Diabetic Ketoacidosis,
pubmed-meshheading:8904928-Female,
pubmed-meshheading:8904928-Glucagon,
pubmed-meshheading:8904928-Humans,
pubmed-meshheading:8904928-Incidence,
pubmed-meshheading:8904928-Insulin Antibodies,
pubmed-meshheading:8904928-Islets of Langerhans,
pubmed-meshheading:8904928-Male,
pubmed-meshheading:8904928-Medical Records,
pubmed-meshheading:8904928-Middle Aged,
pubmed-meshheading:8904928-Turkey
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Frequency of insulin-dependent diabetes mellitus in Turkish adult-onset diabetic population.
|
| pubmed:affiliation |
Department of Internal Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.
|
| pubmed:publicationType |
Journal Article
|