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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1997-1-6
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pubmed:abstractText |
The novel amino acid 8(S)-amino-2(R)-methyl-7-oxononanoic acid (1) was isolated from the soil-borne microorganism Streptomyces diastaticus during our screening for inhibitors of leukotriene-A4 hydrolase (LTA4H), a requisite enzyme in the biosynthesis of the potent inflammatory mediator leukotriene-B4 (LTB4). The structure of 1 was determined by detailed spectroscopic analyses and is related to 7-keto-8-aminopelargonic acid (2), a biosynthetic precursor of biotin. The relative potency of 1 (LTA4H IC50 = 0.6 microM) warranted further biological studies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0163-3864
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
962-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8904845-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:8904845-Animals,
pubmed-meshheading:8904845-Biotin,
pubmed-meshheading:8904845-Enzyme Inhibitors,
pubmed-meshheading:8904845-Epoxide Hydrolases,
pubmed-meshheading:8904845-Fatty Acids,
pubmed-meshheading:8904845-Humans,
pubmed-meshheading:8904845-Leukotriene B4,
pubmed-meshheading:8904845-Protease Inhibitors,
pubmed-meshheading:8904845-Rabbits,
pubmed-meshheading:8904845-Streptomyces,
pubmed-meshheading:8904845-Thromboxane B2
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pubmed:year |
1996
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pubmed:articleTitle |
Isolation and structure of leukotriene-A4 hydrolase inhibitor: 8(S)-amino-2(R)-methyl-7-oxononanoic acid produced by Streptomyces diastaticus.
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pubmed:affiliation |
Searle Research and Development, Monsanto Company, St. Louis, Missouri 63198, USA.
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pubmed:publicationType |
Journal Article
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