Linked Life Data

8902886

Source:http://linkedlifedata.com/resource/pubmed/id/8902886

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1997-2-18
pubmed:abstractText
It was previously reported that selection for differences in the hypothermic effects to the selective 5-HT-1A agonist, 8-OH-DPAT, occurred rapidly, with very substantial differences present by the fourth generation. The present communication summarizes the findings from the next five generations of selection and from behavioral and other functional studies on these rats. The rats which were more sensitive to 8-OH-DPAT (High DPAT Sensitive-HDS) exhibited decreases in temperature of 4 degrees C or more and the distribution did not overlap with that of the rats which were less sensitive to 8-OH-DPAT (Low DPAT Sensitive-LDS) which exhibited decreases in temperature of 1.5 degrees C or less. The randomly bred control group (Random DPAT Sensitive-RDS) exhibited intermediate temperature decreases (means of 1.6-1.8 degrees C), with time overlap with the distributions of the selected groups. Pretreatment with pindolol, a 5-HT-1A antagonist, reduced the hypothermic response to 8-OH-DPAT, but pretreatment with ritanserin, a 5-HT-7 and 5-HT-2A/C antagonist, had no effect, confirming that the hypothermic response to 8-OH-DPAT is mediated predominantly by 5-HT-1A receptors. The HDS rats were less mobile in a forced swim test and drank more saccharin solution in a two-bottle choice paradigm than the LDS or RDS rats over several generations. In contrast, there were no consistent differences among the groups for open field activity or performance in an elevated plus maze. There were no differences among the groups for voluntary alcohol intake, but the HDS rats exhibited greater suppression of alcohol and saccharin intake after injection of 8-OH-DPAT (0.125 mg kg-1). The HDS rats were also found to have a higher number of 5-HT-1A binding sites in cortical regions than the LDS or RDS rats, but there were no 5-HT-1A binding site differences in the raphe nuclei. These findings clearly show that consistent behavioral differences do occur in the 8-OH-DPAT-selected lines of rats, but only for behaviors related to possible depression or reward, not anxiety. The pattern of binding results suggests that these behavioral correlates of 8-OH-DPAT selection may be related to changes in cortical 5-HT-1A receptors rather than raphe autoreceptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0955-8829
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
107-17
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:8902886-8-Hydroxy-2-(di-n-propylamino)tetralin, pubmed-meshheading:8902886-Animals, pubmed-meshheading:8902886-Body Temperature, pubmed-meshheading:8902886-Crosses, Genetic, pubmed-meshheading:8902886-Ethanol, pubmed-meshheading:8902886-Female, pubmed-meshheading:8902886-Food Preferences, pubmed-meshheading:8902886-Male, pubmed-meshheading:8902886-Maze Learning, pubmed-meshheading:8902886-Motor Activity, pubmed-meshheading:8902886-Pindolol, pubmed-meshheading:8902886-Rats, pubmed-meshheading:8902886-Rats, Inbred Strains, pubmed-meshheading:8902886-Receptors, Serotonin, pubmed-meshheading:8902886-Receptors, Serotonin, 5-HT1, pubmed-meshheading:8902886-Ritanserin, pubmed-meshheading:8902886-Saccharin, pubmed-meshheading:8902886-Selection, Genetic, pubmed-meshheading:8902886-Serotonin Antagonists, pubmed-meshheading:8902886-Serotonin Receptor Agonists, pubmed-meshheading:8902886-Taste
pubmed:year
1996
pubmed:articleTitle
Further selection of rat lines differing in 5-HT-1A receptor sensitivity: behavioral and functional correlates.
pubmed:affiliation
Skipper Bowles Center for Alcohol Studies, University of North Carolina School of Medicine at Chapel Hill 27599-7178, USA. dhover@med.unc.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.