| pubmed-article:890247 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:890247 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:890247 | lifeskim:mentions | umls-concept:C0038895 | lld:lifeskim |
| pubmed-article:890247 | lifeskim:mentions | umls-concept:C0597297 | lld:lifeskim |
| pubmed-article:890247 | lifeskim:mentions | umls-concept:C0439608 | lld:lifeskim |
| pubmed-article:890247 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:890247 | pubmed:dateCreated | 1977-10-20 | lld:pubmed |
| pubmed-article:890247 | pubmed:abstractText | Whole body protein turnover was measured in 11 patients before and after elective orthopaedic operations be giving 15N-glycine orally every 4 hours for 32 hours. The patients were maintained throughout on a constant protein intake. In 2 control subjects a comparison was made between intermittent dosage and continuous infusion of 15N-glycine for the estimation of total protein turnover. With intermittent dosage the 15N abundance in urinary urea reached a constant level after about 24 hours. Rates of total protein synthesis and breakdown were calculated from the 15N abundance at the plateau level. After surgery there was a moderate increase in urinary N output. The apparent N balance (intake--urinary N) was -0-52 +/- 1-31 g/d (mean +/- s.d.) before operation and -7-51 +/- 4-5 g/d after operation. The rate of protein synthesis fell from 3-83 +/- 0-73 g kg-1 d-1 before operation to 2-94 +/- 0-83 g kg-1 d-1 after operation. This difference is statistically significant (0-05 greater than P greater than 0-01). There was no significant change in the rate of protein breakdown. The possibility remains that a block in protein synthesis, probably mainly in muscle, may be partly responsible for the so-called 'catabolic' loss of nitrogen after injury, but this has not been proved. | lld:pubmed |
| pubmed-article:890247 | pubmed:language | eng | lld:pubmed |
| pubmed-article:890247 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:890247 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:890247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:890247 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:890247 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:890247 | pubmed:issn | 0007-1323 | lld:pubmed |
| pubmed-article:890247 | pubmed:author | pubmed-author:SmithRR | lld:pubmed |
| pubmed-article:890247 | pubmed:author | pubmed-author:WaterlowJ CJC | lld:pubmed |
| pubmed-article:890247 | pubmed:author | pubmed-author:CraneC WCW | lld:pubmed |
| pubmed-article:890247 | pubmed:author | pubmed-author:PicouDD | lld:pubmed |
| pubmed-article:890247 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:890247 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:890247 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:890247 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:890247 | pubmed:pagination | 129-33 | lld:pubmed |
| pubmed-article:890247 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:890247 | pubmed:meshHeading | pubmed-meshheading:890247-J... | lld:pubmed |
| pubmed-article:890247 | pubmed:year | 1977 | lld:pubmed |
| pubmed-article:890247 | pubmed:articleTitle | Protein turnover in patients before and after elective orthopaedic operations. | lld:pubmed |
| pubmed-article:890247 | pubmed:publicationType | Journal Article | lld:pubmed |
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