Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-3-10
pubmed:abstractText
A severe shortage of human transplant donors has sparked interest in the use of animals as a source of organs and tissues for transplantation. Clinical application of xenotransplantation is limited in large part by the severe immunological reaction of the recipient against the graft. This immunological reaction is mediated initially by components of natural immunity such as xenoreactive antibodies, complement and natural killer cells and later by elicited humoral and cellular immune responses which act in concert to disrupt the function of the endothelial lining of blood vessels. The past few years have brought considerable progress in elucidating the molecular and cellular basis of xenograft rejection and in developing strategies to overcome xenograft rejection.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0952-7915
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
721-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Xenotransplantation: recent progress and current perspectives.
pubmed:affiliation
Department of Surgery, Duke University, Durham, North Carolina 27710, USA. platt001@mc.duke.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't