|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1977-10-28
|
|
pubmed:abstractText |
1 The effects of hemicholinium no. 3 (HC-3) and its p-terphenyl analogue (TPHC-3) on the disposition and distribution of free choline were studied in rabbits under pentobarbitone anaesthesia. Free choline was determined by bioassay. 2 The respiration of animals given 0.35 mumol/kg of HC-3 was hardly affected; however, 4 out of 6 rabbits given the same dose of TPHC-3 exhibited varying degrees of respiratory impairment. All animals that received 2 injections (1 h apart) of either HC-3 (1.4 mumol/kg) or TPHC-3 (0.7 mumol/kg) developed respiratory difficulty about 1 h after the second injection. 3 The respiratory distress was accompanied by a 2 to 15-fold rise in plasma choline concentration. This rise has been attributed to hypoxia. 4 In experiments in which choline has been infused it was observed that HC-3 could impair the animal's ability to dispose of exogenous choline. In control rabbits neither HC-3 nor TPHC-3 produced changes in plasma choline concentrations unless the respiration was depressed. 5 Either HC-3 or TPHC-3 (both at 0.35 mumol/kg) significantly (P less than 0.05) reduced the kidney choline concentration by 40% and 30% respectively; both hemicholiniums raised the lung choline concentration by about 35%. Only TPHC-3 caused a significant rise (40%) in liver choline. The choline concentrations in other tissues were unaffected by the hemicholiniums.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/890206-13129117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/890206-13272163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/890206-13896875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/890206-13924705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/890206-14456669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/890206-4294070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/890206-4387450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/890206-4646586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/890206-4745210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/890206-4854729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/890206-5068132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/890206-5129269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/890206-5800046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/890206-5900219
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0007-1188
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
60
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
351-6
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1977
|
|
pubmed:articleTitle |
Effect of two hemicholiniums on the disposition and distribution of endogenous free choline in anaesthetized rabbits.
|
|
pubmed:publicationType |
Journal Article
|
