Linked Life Data

8901199

Source:http://linkedlifedata.com/resource/pubmed/id/8901199

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1997-2-21
pubmed:abstractText
At the onset of neural development, pioneer growth cones can migrate over epithelia or neuroepithelia along stereotyped routes that establish the pattern of initial neural tracts. These migration routes may reflect the arrangement of distinct epithelial or neuroepithelial domains. In grasshopper limb buds, a pair of afferent pioneer neurons arise in the tibia and their growth cones migrate on a stereotyped path through the limb to the CNS. In the limb buds, circumferentially-oriented epithelial domains expressing semaphorin-I, annulin, or alkaline-phosphatase, and a longitudinal domain, expressing engrailed, have been described. Using multiple-labeling techniques, we describe the relationships of these domains to each other and to the pioneer neuron pathway. Taken together, these domains establish an orthogonal pattern of regionally specific epithelial molecular markers. During much of their migration across the limb epithelium, the pioneer growth cones are in register with the axes of circumferential or longitudinal epithelial domains.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0214-6282
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
965-73
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Pioneer growth cone migration in register with orthogonal epithelial domains in the grasshopper limb bud.
pubmed:affiliation
Department of Molecular and Cell Biology, University of California, Berkeley 94720-3200, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.