| pubmed-article:8901001 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8901001 | lifeskim:mentions | umls-concept:C0036572 | lld:lifeskim |
| pubmed-article:8901001 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8901001 | lifeskim:mentions | umls-concept:C0035868 | lld:lifeskim |
| pubmed-article:8901001 | lifeskim:mentions | umls-concept:C0234378 | lld:lifeskim |
| pubmed-article:8901001 | lifeskim:mentions | umls-concept:C0068821 | lld:lifeskim |
| pubmed-article:8901001 | lifeskim:mentions | umls-concept:C0085196 | lld:lifeskim |
| pubmed-article:8901001 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:8901001 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8901001 | lifeskim:mentions | umls-concept:C0214185 | lld:lifeskim |
| pubmed-article:8901001 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:8901001 | pubmed:dateCreated | 1997-1-23 | lld:pubmed |
| pubmed-article:8901001 | pubmed:abstractText | The present behavioral study was undertaken to investigate whether neuronal nitric oxide (NO) synthase mediates the abnormal consequences of increased NMDA receptor-mediated synaptic transmission in models of postural tremor, Parkinson's disease and epilepsy. We used 7-nitroindazole, a selective inhibitor of neuronal NO synthase, and NG-nitro-L-arginine (L-NAME), an unspecific NO synthase inhibitor, and compared their action with that of the competitive NMDA receptor antagonist 3-[(R)-2-carboxypiperazin-4-yl]-prop-2-enyl-1-phosphonic acid (D-CPPene). In both mice and rats, 7-nitroindazole, L-NAME and D-CPPene dose dependently reversed the harmaline-induced increase of cerebellar cyclic guanosine-5'-monophosphate (cGMP) levels. For subsequent behavioral experiments we used doses of 7-nitroindazole, L-NAME and D-CPPene which were equipotent in preventing harmaline-induced cGMP increase. Harmaline-induced tremor in mice and rats was suppressed by D-CPPene, but not by 7-nitroindazole or by L-NAME. This effect of D-CPPene was not due to unspecific suppression of motor activity, since D-CPPene did not affect locomotor activity at doses which reduced tremor. D-CPPene, but not 7-nitroindazole and L-NAME potentiated the antiparkinsonian action of the dopamine agonist lisuride in rats with unilateral 6-hydroxydopamine lesions of the substantia nigra. D-CPPene antagonized seizures induced by intracerebroventricular injection of NMDA in mice. In contrast, 7-nitroindazole and L-NAME had only a tendency to prevent seizures and to delay the latency to onset of seizures. We conclude from these results that neuronal NO synthase does not serve as a major mediator of increased NMDA receptor-mediated synaptic transmission in animal models of Parkinson's disease, postural tremor and epilepsy. The novel observation that D-CPPene suppresses harmaline-induced tremor leads us to suggest that NMDA receptor antagonists should be considered as novel therapeutics for postural tremor. | lld:pubmed |
| pubmed-article:8901001 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8901001 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8901001 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8901001 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8901001 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8901001 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8901001 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8901001 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:8901001 | pubmed:author | pubmed-author:TurskiLL | lld:pubmed |
| pubmed-article:8901001 | pubmed:author | pubmed-author:LöschmannP... | lld:pubmed |
| pubmed-article:8901001 | pubmed:author | pubmed-author:KlockgetherTT | lld:pubmed |
| pubmed-article:8901001 | pubmed:author | pubmed-author:WüllnerUU | lld:pubmed |
| pubmed-article:8901001 | pubmed:author | pubmed-author:EblenFF | lld:pubmed |
| pubmed-article:8901001 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8901001 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:8901001 | pubmed:volume | 299 | lld:pubmed |
| pubmed-article:8901001 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8901001 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8901001 | pubmed:pagination | 9-16 | lld:pubmed |
| pubmed-article:8901001 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8901001 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8901001 | pubmed:articleTitle | Effects of 7-nitroindazole, NG-nitro-L-arginine, and D-CPPene on harmaline-induced postural tremor, N-methyl-D-aspartate-induced seizures, and lisuride-induced rotations in rats with nigral 6-hydroxydopamine lesions. | lld:pubmed |
| pubmed-article:8901001 | pubmed:affiliation | Department of Neurology, University of Tübingen, Germany. | lld:pubmed |
| pubmed-article:8901001 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8901001 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8901001 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8901001 | lld:pubmed |
