8901001

Source:http://linkedlifedata.com/resource/pubmed/id/8901001

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0034693, umls-concept:C0035868, umls-concept:C0036572, umls-concept:C0068821, umls-concept:C0085196, umls-concept:C0214185, umls-concept:C0221198, umls-concept:C0234378, umls-concept:C1280500
pubmed:issue	1-3
pubmed:dateCreated	1997-1-23
pubmed:abstractText	The present behavioral study was undertaken to investigate whether neuronal nitric oxide (NO) synthase mediates the abnormal consequences of increased NMDA receptor-mediated synaptic transmission in models of postural tremor, Parkinson's disease and epilepsy. We used 7-nitroindazole, a selective inhibitor of neuronal NO synthase, and NG-nitro-L-arginine (L-NAME), an unspecific NO synthase inhibitor, and compared their action with that of the competitive NMDA receptor antagonist 3-[(R)-2-carboxypiperazin-4-yl]-prop-2-enyl-1-phosphonic acid (D-CPPene). In both mice and rats, 7-nitroindazole, L-NAME and D-CPPene dose dependently reversed the harmaline-induced increase of cerebellar cyclic guanosine-5'-monophosphate (cGMP) levels. For subsequent behavioral experiments we used doses of 7-nitroindazole, L-NAME and D-CPPene which were equipotent in preventing harmaline-induced cGMP increase. Harmaline-induced tremor in mice and rats was suppressed by D-CPPene, but not by 7-nitroindazole or by L-NAME. This effect of D-CPPene was not due to unspecific suppression of motor activity, since D-CPPene did not affect locomotor activity at doses which reduced tremor. D-CPPene, but not 7-nitroindazole and L-NAME potentiated the antiparkinsonian action of the dopamine agonist lisuride in rats with unilateral 6-hydroxydopamine lesions of the substantia nigra. D-CPPene antagonized seizures induced by intracerebroventricular injection of NMDA in mice. In contrast, 7-nitroindazole and L-NAME had only a tendency to prevent seizures and to delay the latency to onset of seizures. We conclude from these results that neuronal NO synthase does not serve as a major mediator of increased NMDA receptor-mediated synaptic transmission in animal models of Parkinson's disease, postural tremor and epilepsy. The novel observation that D-CPPene suppresses harmaline-induced tremor leads us to suggest that NMDA receptor antagonists should be considered as novel therapeutics for postural tremor.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/1254354
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/7-nitroindazole, http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Harmaline, http://linkedlifedata.com/resource/pubmed/chemical/Hydroxydopamines, http://linkedlifedata.com/resource/pubmed/chemical/Indazoles, http://linkedlifedata.com/resource/pubmed/chemical/Lisuride, http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase, http://linkedlifedata.com/resource/pubmed/chemical/Nitroarginine, http://linkedlifedata.com/resource/pubmed/chemical/Piperazines, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate, http://linkedlifedata.com/resource/pubmed/chemical/SDZ EAA 494
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	0014-2999
pubmed:author	pubmed-author:EblenFF, pubmed-author:KlockgetherTT, pubmed-author:LöschmannP APA, pubmed-author:TurskiLL, pubmed-author:WüllnerUU
pubmed:issnType	Print
pubmed:day	28
pubmed:volume	299
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	9-16
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:8901001-Animals, pubmed-meshheading:8901001-Anticonvulsants, pubmed-meshheading:8901001-Behavior, Animal, pubmed-meshheading:8901001-Brain, pubmed-meshheading:8901001-Cyclic GMP, pubmed-meshheading:8901001-Dose-Response Relationship, Drug, pubmed-meshheading:8901001-Drug Interactions, pubmed-meshheading:8901001-Enzyme Inhibitors, pubmed-meshheading:8901001-Excitatory Amino Acid Antagonists, pubmed-meshheading:8901001-Harmaline, pubmed-meshheading:8901001-Hydroxydopamines, pubmed-meshheading:8901001-Indazoles, pubmed-meshheading:8901001-Lisuride, pubmed-meshheading:8901001-Locomotion, pubmed-meshheading:8901001-Male, pubmed-meshheading:8901001-N-Methylaspartate, pubmed-meshheading:8901001-Nitric Oxide Synthase, pubmed-meshheading:8901001-Nitroarginine, pubmed-meshheading:8901001-Piperazines, pubmed-meshheading:8901001-Rats, pubmed-meshheading:8901001-Receptors, N-Methyl-D-Aspartate, pubmed-meshheading:8901001-Seizures
pubmed:year	1996
pubmed:articleTitle	Effects of 7-nitroindazole, NG-nitro-L-arginine, and D-CPPene on harmaline-induced postural tremor, N-methyl-D-aspartate-induced seizures, and lisuride-induced rotations in rats with nigral 6-hydroxydopamine lesions.
pubmed:affiliation	Department of Neurology, University of Tübingen, Germany.
pubmed:publicationType	Journal Article, Comparative Study, Research Support, Non-U.S. Gov't