Linked Life Data

8900498

Source:http://linkedlifedata.com/resource/pubmed/id/8900498

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-1-13
pubmed:abstractText
Tracheal strips from normal and actively sensitized guinea pigs were studied to determine the responses to serotonin (5-hydroxytryptamine, 5-HT; 1 nM-0.1 mM) and ouabain (0.1 microM-0.1 mM), and the effects of increasing the extracellular calcium (Cao) concentration on tonic contractions elicited by 5-HT. Sensitized trachea exhibited an increased responsiveness and sensitivity to 5-HT and ouabain. Increases in Cao to achieve final concentrations of 5, 10 and 20 mM caused concentration-related relaxations of normal and sensitized tissues contracted to a similar plateau level with 5-HT. Inhibition of the Na+/K(+)-ATPase by ouabain (10 microM) reversed the effects of Cao from relaxation to contraction in normal and sensitized tissues contracted with 5HT. Sensitized preparations showed reduced relaxations in response to Cao (10-20 mM), and sensitized, ouabain-treated, trachea showed augmented contractions to Cao (10-20 mM) when compared to normal tissues. These results demonstrate a decreased membrane-stabilizing effect of Cao in sensitized trachea and the implication of the Na+/K(+)-ATPase in the regulation of membrane stability by Cao, suggesting a possible relevance to those mechanisms underlying airway hyperreactivity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0767-3981
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
33-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Effect of serotonin and calcium in normal and sensitized guinea pig isolated trachea.
pubmed:affiliation
Servicio de Neumología, Hospital Universitario La Fe, Valencia, Spain.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't