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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0002938,
umls-concept:C0008651,
umls-concept:C0012854,
umls-concept:C0017262,
umls-concept:C0185117,
umls-concept:C0376515,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0919553,
umls-concept:C1517945,
umls-concept:C1520972,
umls-concept:C1527349,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C2911684
|
| pubmed:issue |
5
|
| pubmed:dateCreated |
1996-12-3
|
| pubmed:abstractText |
Chromosome 1 abnormalities with loss of 1p36 have been investigated in 95 breast-cancer samples by means of a dual-target fluorescence in-situ hybridization (FISH) technique using the pUC 1.77 and p1-79 probes, specific for the 1q12 and 1p36 regions, respectively. Abnormalities for one or both probes were detected in 83/95 samples. Relative 1p36 under-representation was found in 79/95. The clinical relevance of these alterations was studied by comparing the FISH results with several parameters currently used in breast-cancer pathology. Distinct patterns of chromosome 1 abnormalities were found among the histologic types of breast carcinoma. Lobular or mucinous samples showed few or no alterations, whereas most ductal samples had high chromosome 1 polysomy with under-representation of 1p36. In ductal carcinomas, chromosome 1 alterations increased with histologic grade, DNA aneuploidy, loss of bcl-2 and high c-erb B-2 expression. These associations were found to be statistically significant. No correlation between chromosome 1 alterations and nuclear grade, age, size, lymph-node involvement, hormonal receptor presence, proliferation activity or p53 protein expression was detected. These results indicate the utility of this FISH technique for a better definition of the biological characteristics of ductal carcinomas.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0020-7136
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
21
|
| pubmed:volume |
69
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
381-5
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:8900371-Adult,
pubmed-meshheading:8900371-Aged,
pubmed-meshheading:8900371-Aneuploidy,
pubmed-meshheading:8900371-Breast Neoplasms,
pubmed-meshheading:8900371-Carcinoma, Ductal, Breast,
pubmed-meshheading:8900371-Cell Division,
pubmed-meshheading:8900371-Chromosome Deletion,
pubmed-meshheading:8900371-Chromosomes, Human, Pair 1,
pubmed-meshheading:8900371-Female,
pubmed-meshheading:8900371-Humans,
pubmed-meshheading:8900371-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8900371-Lymphocytes,
pubmed-meshheading:8900371-Middle Aged,
pubmed-meshheading:8900371-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:8900371-Receptor, erbB-2,
pubmed-meshheading:8900371-Receptors, Estrogen,
pubmed-meshheading:8900371-Receptors, Progesterone,
pubmed-meshheading:8900371-Tumor Suppressor Protein p53
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Chromosome 1 aneusomy with 1p36 under-representation is related to histologic grade, DNA aneuploidy, high c-erb B-2 and loss of bcl-2 expression in ductal breast carcinoma.
|
| pubmed:affiliation |
Department of Experimental Pathology, University of Bologna, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|