Linked Life Data

8899974

Source:http://linkedlifedata.com/resource/pubmed/id/8899974

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1997-2-6
pubmed:abstractText
Immunization assays were performed in NMRI mice using urea extracts from both the S-form and an R-mutant of S. typhimurium. Our results show that, apart from providing protection against infection, both vaccines induced a DTH (delayed type hypersensitivity) reaction against the antigen extract. The strength of the DTH reaction depended on the type of test antigen used, the urea extracts proving to be superior to extracts obtained by ultrasonication. With the urea extract, all animals responded in the foot pad test. Both parameters of the immune response, protection against infection and the strength of DTH, could be further enhanced by a lipopeptide adjuvant, which was effective both in mixture and conjugate form; the humoral immune response was not enhanced. Thus, urea extract vaccines from S. typhimurium induce a cell-mediated response which can be further enhanced by lipopeptide adjuvants.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0934-8840
pubmed:author
pubmed:issnType
Print
pubmed:volume
284
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
559-64
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Protection against bacterial infection by urea extracts from Salmonella.
pubmed:affiliation
Max-Planck-Institut für Immunbiologie, Freiburg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't