|
rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
10
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pubmed:dateCreated |
1997-3-31
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|
pubmed:abstractText |
The absorption and disposition of selegiline (SEL) and its metabolites N-desmethylselegiline (DMS), L-methamphetamine (MET), and L-amphetamine (AMP) were assessed in 8 healthy male volunteers at proximal and distal regions of the intestine relative to oral administration (in the stomach) to determine if intestinal site dependence contributed to the erratic oral absorption of selegiline hydrochloride which is manifest as low and variable bioavailability.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0724-8741
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
13
|
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1535-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8899847-Administration, Oral,
pubmed-meshheading:8899847-Adult,
pubmed-meshheading:8899847-Amphetamine,
pubmed-meshheading:8899847-Amphetamines,
pubmed-meshheading:8899847-Biological Availability,
pubmed-meshheading:8899847-Cross-Over Studies,
pubmed-meshheading:8899847-Duodenum,
pubmed-meshheading:8899847-Humans,
pubmed-meshheading:8899847-Ileum,
pubmed-meshheading:8899847-Intestinal Absorption,
pubmed-meshheading:8899847-Intestines,
pubmed-meshheading:8899847-Jejunum,
pubmed-meshheading:8899847-Male,
pubmed-meshheading:8899847-Methamphetamine,
pubmed-meshheading:8899847-Monoamine Oxidase Inhibitors,
pubmed-meshheading:8899847-Selegiline,
pubmed-meshheading:8899847-Stomach
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|
pubmed:year |
1996
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|
pubmed:articleTitle |
Absorption and presystemic metabolism of selegiline hydrochloride at different regions in the gastrointestinal tract in healthy males.
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|
pubmed:affiliation |
Pharmacokinetics Department, Somerset Pharmaceuticals, Tampa, Florida 33607, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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