|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1997-2-7
|
|
pubmed:abstractText |
While oligoclonality of circulating CD4- CD8 and of CD8+ T cells is not uncommon, clonal dominance within the CD4 compartment is not frequently found in healthy individuals. In contrast, the majority of patients with rheumatoid arthritis (RA) have clonally expanded CD4+ T cell populations. Previous studies have demonstrated that these clonogenic CD4+ T cells do not express the CD28 molecule. To examine the correlation between CD28 expression and clonal proliferation, we have analyzed the T cell receptor (TCR) diversity of CD4+ CD28- T cells in normal individuals and in RA patients.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-1281285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-1380061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-1591005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-1693083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-1833769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-1972592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-2197981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-2478624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-2479030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-3340835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-3358796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-7481803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-7500046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-7505446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-7546402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-7584144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-7621080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-7688514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-7846057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-7897233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-7962553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-8064234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-8176227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-8228260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-8258683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-8294871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-8381831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-8386518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-8386744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-8391057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-8483950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-8496681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-8529128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-8557973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-8621791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8898376-8651983
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1076-1551
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
2
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
608-18
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:8898376-Amino Acid Sequence,
pubmed-meshheading:8898376-Antigens, CD28,
pubmed-meshheading:8898376-Antigens, CD4,
pubmed-meshheading:8898376-Arthritis, Rheumatoid,
pubmed-meshheading:8898376-Cell Compartmentation,
pubmed-meshheading:8898376-Cell Separation,
pubmed-meshheading:8898376-Conserved Sequence,
pubmed-meshheading:8898376-Flow Cytometry,
pubmed-meshheading:8898376-Humans,
pubmed-meshheading:8898376-Molecular Sequence Data,
pubmed-meshheading:8898376-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8898376-T-Lymphocytes
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
The repertoire of CD4+ CD28- T cells in rheumatoid arthritis.
|
|
pubmed:affiliation |
Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
