Linked Life Data

889826

Source:http://linkedlifedata.com/resource/pubmed/id/889826

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1977-10-14
pubmed:abstractText
Changes in the membrane capacity of squid axons during hyper- and depolarizations are measured between --160 and +40 mV. After corrections for the series resistance and fringe effect, we found that the membrane capacity increased from 0.68 to 1.2 muF/cm2 with depolarization. It was further observed that tetrodotoxin the external medium eliminated the change in membrane capacity without affecting the conductivity. The voltage-dependent membrane conductivity is, in turn, greatley reduced by the internal cesium ion. These observations clearly indicate that the voltage-dependent membrane capacity and conductivity are closely related to ionic channels. Particularly, the increase in membrane capacity with depolarizations may be due to sodium channels. The change in the dipole moment associated with sodium sites was determined using values of alpham and betam at various depolarizations. We found, based on voltage clamp measurements, that the increase in the dipole moment of the sodium site between --40 and --5 mV is 1230 Debye units (D.U.) and 930 D.U. between --5 and +60mV, indicating that the depolarization of sodium channels may consist of two different steps.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-3002
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
469
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
74-88
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Dipole moment changes and voltage dependent membrane capacity of squid axon.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.