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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4 Pt 2
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pubmed:dateCreated |
1996-12-16
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pubmed:abstractText |
Mechanisms of circulatory effects induced by nitric oxide synthase inhibition in endotoxemia were investigated in 36 pigs randomized to 1) endotoxin infusion (1.7 micrograms.kg-1.h-1 iv) for 7 h and bolus NG-nitro-L-arginine methyl ester (L-NAME; 25 mg/kg iv) after 3 h; 2) endotoxin infusion for 7 h; 3) saline infusion for 7 h and L-NAME after 3 h; and 4) saline infusion for 7 h. Fifteen minutes after L-NAME injection during endotoxemia, reductions in cardiac output (41%, P < 0.05), portal venous flow (51%, P < 0.05), and hepatic artery flow (50%, P < 0.05) were observed. Systemic vascular resistance increased by 82% (P < 0.05), and the portocaval vascular resistance increased by 101% (P < 0.05). Despite marked vasoconstriction after L-NAME, left ventricular intracavitary filling pressure, central venous pressure, and arterial pressure remained unchanged. During endotoxemia, hematocrit increased from 38.4 +/- 1.4 to 41.9 +/- 1.2 after L-NAME, and blood volume (n = 3) was reduced by an average of 8.3 ml/kg body wt. These changes probably reflect transcapillary fluid loss as urine output was unchanged. In conclusion, L-NAME decreased intravascular blood volume and increased splanchnic venous resistance. These effects will tend to reduce venous return. Combined with a marked increase in left ventricular after-load, L-NAME may thus compromise cardiovascular function in endotoxemia.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0002-9513
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
271
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
H1325-32
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8897924-Animals,
pubmed-meshheading:8897924-Blood Volume,
pubmed-meshheading:8897924-Endotoxemia,
pubmed-meshheading:8897924-Endotoxins,
pubmed-meshheading:8897924-Enzyme Inhibitors,
pubmed-meshheading:8897924-Female,
pubmed-meshheading:8897924-Hematocrit,
pubmed-meshheading:8897924-Hemodynamics,
pubmed-meshheading:8897924-Liver Circulation,
pubmed-meshheading:8897924-Male,
pubmed-meshheading:8897924-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:8897924-Nitric Oxide Synthase,
pubmed-meshheading:8897924-Portal System,
pubmed-meshheading:8897924-Splanchnic Circulation,
pubmed-meshheading:8897924-Swine,
pubmed-meshheading:8897924-Veins
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pubmed:year |
1996
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pubmed:articleTitle |
Nitric oxide synthase inhibition reduces venous return in porcine endotoxemia.
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pubmed:affiliation |
Institute for Surgical Research, National Hospital, Oslo, Norway.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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