Linked Life Data

8897164

Source:http://linkedlifedata.com/resource/pubmed/id/8897164

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1997-3-10
pubmed:abstractText
A six-laboratory collaborative study was conducted to develop MIC and zone diameter quality control limits and interpretive criteria for antimicrobial susceptibility testing of Streptococcus pneumoniae with azithromycin, clarithromycin, dirithromycin, and clindamycin. The MICs of all of the agents plus erythromycin for 302 clinical isolates of pneumococci that had been selected with an emphasis on resistant strains were determined by use of the National Committee for Clinical Laboratory Standards (NCCLS)-recommended broth microdilution procedure. The zone diameters of the isolates were also determined for the same agents except erythromycin by the NCCLS disk diffusion test procedure. Repeated testing of S. pneumoniae ATCC 49619 with different sources and lots of media and disks allowed development of MIC and zone diameter quality control ranges for these agents. Interpretive criteria for the MIC of azithromycin were established and were as follows: susceptible, < or = 0.5 microgram/ml; intermediate, 1 microgram/ml; and resistant, > or = 2 micrograms/ml. The interpretive criteria advocated for the MICs of clarithromycin and clindamycin were as follows: susceptible, < or = 0.25 microgram/ml; intermediate, 0.5 microgram/ml; and resistant, > or = 1 microgram/ml. Comparison of MICs and disk diffusion zone diameters led to the development of interpretive criteria for the zone diameters for azithromycin, clarithromycin, and clindamycin that correlated well with these MIC breakpoints. Testing of this organism collection also led to the reestablishment of the erythromycin MIC breakpoints as being identical to those of clarithromycin, which resulted in equivalent cross-susceptibility and cross-resistance for the three macrolides that are currently marketed in the United States. Thus, the susceptibility of pneumococci to azithromycin and clarithromycin can be predicted accurately by testing only erythromycin in clinical laboratories. This recommendation, as well as the interpretive and quality control criteria that are described, have been accepted by NCCLS and are included in the latest NCCLS susceptibility testing guidelines.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8897164-1617051, http://linkedlifedata.com/resource/pubmed/commentcorrection/8897164-1636656, http://linkedlifedata.com/resource/pubmed/commentcorrection/8897164-2187594, http://linkedlifedata.com/resource/pubmed/commentcorrection/8897164-2684004, http://linkedlifedata.com/resource/pubmed/commentcorrection/8897164-4372272, http://linkedlifedata.com/resource/pubmed/commentcorrection/8897164-6455443, http://linkedlifedata.com/resource/pubmed/commentcorrection/8897164-7623880, http://linkedlifedata.com/resource/pubmed/commentcorrection/8897164-7814481, http://linkedlifedata.com/resource/pubmed/commentcorrection/8897164-8028618, http://linkedlifedata.com/resource/pubmed/commentcorrection/8897164-8196139, http://linkedlifedata.com/resource/pubmed/commentcorrection/8897164-8843287, http://linkedlifedata.com/resource/pubmed/commentcorrection/8897164-8843313
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0095-1137
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2679-84
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Development of interpretive criteria and quality control limits for macrolide and clindamycin susceptibility testing of Streptococcus pneumoniae.
pubmed:affiliation
Department of Pathology, University of Texas Health Science Center, San Antonio 78284-7750, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't