Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1996-12-16
pubmed:databankReference
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74662, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74663, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74664, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74665, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74667, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74668, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74670, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74671, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74672, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74673, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74674, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74675, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74676, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74677, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74678, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74679, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74680, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74681, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74682, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74683, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74684, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74685, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74686, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74687, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74691, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74692, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74693, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74694, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/Z74695
pubmed:abstractText
Tumor cell lines and one tumor biopsy from seven cases of Epstein-Barr virus (EBV) genome-negative sporadic Burkitt's lymphoma (BL) have been investigated for usage and mutational pattern of Ig variable region genes. The VH genes were derived from the VH 3 (one) and VH4 (six) families and both the IgM-positive (six) and the IgA-positive (one) were all mutated from their germline counterparts. The VL genes were derived from V kappa 1 (one), V kappa 3 (one), V lambda 1 (four), and V lambda 2 (one) families and were also somatically hypermutated. Biopsy material from one of the IgM-positive cases showed VH and VL sequences that matched the derived cell line, with additional intraclonal sequence heterogeneity, indicating that the tumor cells had undergone posttranformation somatic mutation. Mutational patterns in V(H) genes did not show a conventional role for antigen in selecting tumor cell sequences. In contrast, patterns in VL sequences were consistent with a role for antigen in five of seven cases. The pattern of extensive scattered somatic hypermutation and intraclonal variation is similar to that in VH sequences of EBV genome-positive endemic BL, although the degree of mutational activity is less. These common features indicate that B cells involved in the two variants of BL may share a common clonal history.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3562-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection.
pubmed:affiliation
Tenovus Laboratory, Southampton University Hospital, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't