Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
1997-1-30
pubmed:abstractText
The aim of this paper was to investigate the influence of preparation parameters on gelatin microspheres production, chemico-physical characteristics and drug encapsulation. In particular, we focussed our attention on the manufacturing parameters such as amount of polymer, stirring speed, presence and concentration of surfactants. As model drugs, TAPP-Br, clonidine hydrochloride and bromocriptine mesylate were chosen in order to compare their encapsulation and release characteristics with microspheres. In the second part of this work, a study of the influence of thermal treatment on the microspheres is reported, performed with the aim to possibly modify gelatin dissolution and drug release. In particular, the effect of this treatment was evaluated on microsphere characteristics such as swelling, porosity and dissolution, and finally on the release profiles of the encapsulated drugs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0142-9612
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2009-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Gelatin microspheres: influence of preparation parameters and thermal treatment on chemico-physical and biopharmaceutical properties.
pubmed:affiliation
Department of Pharmaceutical Sciences, University of Ferrara, Italy.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't