Linked Life Data

8893762

Source:http://linkedlifedata.com/resource/pubmed/id/8893762

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1996-12-4
pubmed:abstractText
The dynamics of longitudinal bone growth are very complex, and potential targets for control could be any one of a number of cells or physiologic processes. Previous studies have demonstrated a linear relationship between hypertrophic cell morphology and bone growth rate in various growth plates and animals. It is unclear whether this relationship varies with age or growth plate. This study tested for significant correlations between mean terminal hypertrophic cell volume and bone growth rate as a function of age and growth plate in the New Zealand White rabbit. Three male rabbits in each of five age groups (2, 3, 5, 8, and 12 weeks old) were used to analyze growth plates from the proximal femur, proximal tibia, and proximal and distal radius. With use of tetracycline labeling and stereological techniques, bone growth rates and hypertrophic chondrocyte volumes were measured. The data were stratified by age and growth plate location and were analyzed using linear regressions. Analyses of covariance were used to test for significant differences. First, there were significant differences due to age. Linear relationships between bone growth rate and hypertrophic chondrocyte volume existed only for the older age groups (all r2 > 0.8), not for the 2 or 3-week-old groups. Also, the slope of the relationship was significantly higher in 5-week-old rabbits than in the 8 and 12-week-old groups. Second, there were significant differences between species. A comparison of the rabbit data with pig and rat data in the literature showed significant differences between all three species. Third, significant differences between growth plates were found. Although hypertrophic chondrocyte volume plays an important role in bone growth, its function may be dependent on age, species, and location.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0736-0266
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
706-11
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Relationship between bone growth rate and hypertrophic chondrocyte volume in New Zealand white rabbits of varying ages.
pubmed:affiliation
Orthopaedic Research Laboratories, University of Michigan, Ann Arbor 48109-0486, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't