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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1996-12-23
|
| pubmed:abstractText |
Whereas low-intensity, high-frequency ultrasound (US) alone appears to cause minimal thrombolysis, US combined with air-filled microbubbles does increase the amount of urokinase (UK)-mediated clot lysis (CL). Because this phenomenon may be mediated by cavitation-induced streaming, we hypothesized that perfluorocarbon-exposed sonicated dextrose albumin (PESDA) microbubbles, which are more stable than air-filled microbubbles, may also enhance US-induced thrombolysis. We measured the percentage CL of equally sized thrombi (1.0 +/- 0.1 mg) made from freshly drawn blood incubated for 2 hours and then exposed to 20 kHz US (0.846 MPa peak negative pressure). The thrombi were bathed in 4 ml of saline solution, UK alone (20,000 U), PESDA alone, or a combination of PESDA with UK. The percentage CL achieved with PESDA and therapeutic US was also compared with the percentage CL achieved with room air-filled sonicated dextrose albumin (RASDA) microbubbles. When compared with US alone (24% +/- 13% CL) or UK alone (17% +/- 3% CL), PESDA plus US produced significantly better CL (43% +/- 17%; p< 0.05). PESDA combined with US also produced significantly greater CL than RASDA combined with US (28% +/- 9%; p < 0.05). The optimal CL was achieved with a combination of PESDA with UK with US (60% +/- 14% CL). We conclude that PESDA microbubbles alone may be capable of inducing thrombolysis when insonified with a low-frequency transducer.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0002-8703
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
132
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
964-8
|
| pubmed:dateRevised |
2006-2-27
|
| pubmed:meshHeading |
pubmed-meshheading:8892768-Contrast Media,
pubmed-meshheading:8892768-Fluorocarbons,
pubmed-meshheading:8892768-Humans,
pubmed-meshheading:8892768-Microspheres,
pubmed-meshheading:8892768-Serum Albumin,
pubmed-meshheading:8892768-Sonication,
pubmed-meshheading:8892768-Thrombolytic Therapy,
pubmed-meshheading:8892768-Ultrasonic Therapy
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Thrombolytic enhancement with perfluorocarbon-exposed sonicated dextrose albumin microbubbles.
|
| pubmed:affiliation |
University of Nebraska Medical Center, Omaha 68198-1165, USA.
|
| pubmed:publicationType |
Journal Article
|