Linked Life Data

8892104

Source:http://linkedlifedata.com/resource/pubmed/id/8892104

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1997-5-13
pubmed:abstractText
How multiple mature phenotypic traits are regulated in developing neurons remains a central problem in developmental neurobiology. Mature sympathetic neurons express general neuronal epitopes, including neuron specific tubulin (NST) as well as markers involved in neurotransmitter synthesis including tyrosine hydroxylase (TH). To investigate the relationship between neuronal differentiation and neurotransmitter development, the order of appearance of NST and TH was determined in both chick and rat embryonic sympathetic ganglia by double-label immunohistochemistry. In differentiated ganglia, these two markers were expressed in virtually all sympathetic neurons examined. By contrast, at early stages of embryonic development in both chick and rat, sympathetic ganglia contained many NST immunoreactive (IR) cells, but few precursors were TH-IR. With further development, more NST-IR cells were also TH-IR, and these two markers gradually became coexpressed with subsequent development. These data provide evidence that general neuronal and neurotransmitter differentiation events are separable and independently regulated during cellular diversification in the adrenergic lineage.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0360-4012
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
42-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Developing sympathetic neurons express a neuronal trait before a catecholaminergic synthetic enzyme in vivo.
pubmed:affiliation
Case Western Reserve University School of Medicine, Department of Neurosciences, Cleveland, OH 44106-4975, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't