| pubmed-article:8891197 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8891197 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:8891197 | lifeskim:mentions | umls-concept:C0010416 | lld:lifeskim |
| pubmed-article:8891197 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8891197 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8891197 | lifeskim:mentions | umls-concept:C2709248 | lld:lifeskim |
| pubmed-article:8891197 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:8891197 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:8891197 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8891197 | pubmed:dateCreated | 1997-2-4 | lld:pubmed |
| pubmed-article:8891197 | pubmed:abstractText | The objective of these studies was to present an overview of our studies of the cytokine network and cellular interactions responsible for the T-cell-mediated inflammatory response in the lungs following infection by Cryptococcus neoformans. In a resistant strain of mice, moderately virulent cryptococci were progressively cleared from the lungs after week 1. Characterization of mitogen-induced cytokine production demonstrated that the T cells in the lungs during the first 3 weeks of infection resembled Th0 rather than Th1 cells. In addition, the production of IL-10 (by mitogen-stimulated leukocytes) could promote an increase in the ratio of Th2:Th1 cytokines in short-term in vitro cultures. In vivo, there were increases in the alveolar levels of tumor necrosis factor-alpha and IL-6 at weeks 1-3 and the chemokines monocyte chemoattractant protein-1 at weeks 1-2 followed by macrophage inflammatory protein-1 alpha and ENA-78 at week 3. Overall, the pulmonary inflammatory response to C. neoformans evolved over 5 weeks from granulocytic to mononuclear, suggesting a maturation to a Th1-type response by week 5. | lld:pubmed |
| pubmed-article:8891197 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8891197 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8891197 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8891197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8891197 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8891197 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8891197 | pubmed:issn | 1016-0922 | lld:pubmed |
| pubmed-article:8891197 | pubmed:author | pubmed-author:HuffnagleG... | lld:pubmed |
| pubmed-article:8891197 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8891197 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:8891197 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8891197 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8891197 | pubmed:pagination | 215-22 | lld:pubmed |
| pubmed-article:8891197 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8891197 | pubmed:meshHeading | pubmed-meshheading:8891197-... | lld:pubmed |
| pubmed-article:8891197 | pubmed:meshHeading | pubmed-meshheading:8891197-... | lld:pubmed |
| pubmed-article:8891197 | pubmed:meshHeading | pubmed-meshheading:8891197-... | lld:pubmed |
| pubmed-article:8891197 | pubmed:meshHeading | pubmed-meshheading:8891197-... | lld:pubmed |
| pubmed-article:8891197 | pubmed:meshHeading | pubmed-meshheading:8891197-... | lld:pubmed |
| pubmed-article:8891197 | pubmed:meshHeading | pubmed-meshheading:8891197-... | lld:pubmed |
| pubmed-article:8891197 | pubmed:meshHeading | pubmed-meshheading:8891197-... | lld:pubmed |
| pubmed-article:8891197 | pubmed:meshHeading | pubmed-meshheading:8891197-... | lld:pubmed |
| pubmed-article:8891197 | pubmed:meshHeading | pubmed-meshheading:8891197-... | lld:pubmed |
| pubmed-article:8891197 | pubmed:meshHeading | pubmed-meshheading:8891197-... | lld:pubmed |
| pubmed-article:8891197 | pubmed:articleTitle | Role of cytokines in T cell immunity to a pulmonary Cryptococcus neoformans infection. | lld:pubmed |
| pubmed-article:8891197 | pubmed:affiliation | Department of Internal Medicine, University of Michigan, Ann Arbor, USA. | lld:pubmed |
| pubmed-article:8891197 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8891197 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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