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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1997-2-4
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pubmed:abstractText |
The objective of these studies was to present an overview of our studies of the cytokine network and cellular interactions responsible for the T-cell-mediated inflammatory response in the lungs following infection by Cryptococcus neoformans. In a resistant strain of mice, moderately virulent cryptococci were progressively cleared from the lungs after week 1. Characterization of mitogen-induced cytokine production demonstrated that the T cells in the lungs during the first 3 weeks of infection resembled Th0 rather than Th1 cells. In addition, the production of IL-10 (by mitogen-stimulated leukocytes) could promote an increase in the ratio of Th2:Th1 cytokines in short-term in vitro cultures. In vivo, there were increases in the alveolar levels of tumor necrosis factor-alpha and IL-6 at weeks 1-3 and the chemokines monocyte chemoattractant protein-1 at weeks 1-2 followed by macrophage inflammatory protein-1 alpha and ENA-78 at week 3. Overall, the pulmonary inflammatory response to C. neoformans evolved over 5 weeks from granulocytic to mononuclear, suggesting a maturation to a Th1-type response by week 5.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1016-0922
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
215-22
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8891197-Animals,
pubmed-meshheading:8891197-Cryptococcosis,
pubmed-meshheading:8891197-Cytokines,
pubmed-meshheading:8891197-Interleukin-10,
pubmed-meshheading:8891197-Interleukin-6,
pubmed-meshheading:8891197-Mice,
pubmed-meshheading:8891197-Mice, Inbred CBA,
pubmed-meshheading:8891197-Pneumonia, Bacterial,
pubmed-meshheading:8891197-T-Lymphocytes,
pubmed-meshheading:8891197-Tumor Necrosis Factor-alpha
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pubmed:articleTitle |
Role of cytokines in T cell immunity to a pulmonary Cryptococcus neoformans infection.
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pubmed:affiliation |
Department of Internal Medicine, University of Michigan, Ann Arbor, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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