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rdf:type |
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lifeskim:mentions |
umls-concept:C0006556,
umls-concept:C0017262,
umls-concept:C0086376,
umls-concept:C0185117,
umls-concept:C0679058,
umls-concept:C0871261,
umls-concept:C1547699,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2700640,
umls-concept:C2911684,
umls-concept:C2911692
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pubmed:issue |
11
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pubmed:dateCreated |
1997-1-6
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pubmed:databankReference |
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pubmed:abstractText |
Previous analysis of hybrid progeny derived from lipopolysaccharide (LPS) responder and nonresponder inbred mouse strains demonstrated that a single genetic locus controlled responsiveness to LPS. Using a differential functional screening approach, we report the isolation of a cDNA that has sequence homology to a GTP-binding protein. Expression of the cDNA in splenic B cells of C3H/HeJ nonresponder, endotoxin-resistant mice resulted in polyclonal B-cell activation in response to LPS stimulation. Thus a GTP-binding protein may be involved in LPS stimulation in B cells and perhaps other cell types.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-1085749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-1398150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-1633874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-1851087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-1855255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-1961752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-202651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-2108320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-2116664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-2122258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-2300055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-2448879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-2476675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-2494654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-2504585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-2537732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-2663468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-3119352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-3304147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-396770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-4539345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-4877918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-530103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-6287227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-6546423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-7685560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-792337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-8057434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-8330899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-8387358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-8421051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8890215-8455603
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4612-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8890215-Amino Acid Sequence,
pubmed-meshheading:8890215-Animals,
pubmed-meshheading:8890215-B-Lymphocytes,
pubmed-meshheading:8890215-Base Sequence,
pubmed-meshheading:8890215-DNA, Complementary,
pubmed-meshheading:8890215-GTP-Binding Proteins,
pubmed-meshheading:8890215-Gene Expression,
pubmed-meshheading:8890215-Lipopolysaccharides,
pubmed-meshheading:8890215-Lymphocyte Activation,
pubmed-meshheading:8890215-Mice,
pubmed-meshheading:8890215-Mice, Inbred C3H,
pubmed-meshheading:8890215-Molecular Sequence Data,
pubmed-meshheading:8890215-Molecular Weight,
pubmed-meshheading:8890215-Monomeric GTP-Binding Proteins,
pubmed-meshheading:8890215-Sequence Homology, Nucleic Acid,
pubmed-meshheading:8890215-ran GTP-Binding Protein
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pubmed:year |
1996
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pubmed:articleTitle |
Restoration of lipopolysaccharide-mediated B-cell response after expression of a cDNA encoding a GTP-binding protein.
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pubmed:affiliation |
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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