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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0002062,
umls-concept:C0003749,
umls-concept:C0003753,
umls-concept:C0016030,
umls-concept:C0017562,
umls-concept:C0018270,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0086418,
umls-concept:C0185023,
umls-concept:C0205164,
umls-concept:C0237497,
umls-concept:C0332261,
umls-concept:C0600210,
umls-concept:C1314972,
umls-concept:C1533691,
umls-concept:C1947904,
umls-concept:C1999228,
umls-concept:C2246343,
umls-concept:C2825781
|
| pubmed:issue |
7
|
| pubmed:dateCreated |
1997-1-30
|
| pubmed:abstractText |
Because betel quid (BQ) chewing has been linked to a higher prevalence of periodontal diseases, the pathobiological effects of arecoline, a main alkaloid found in areca nut, were investigated in cultured human gingival fibroblasts. At concentrations higher than 0.4 mM, arecoline inhibits cell attachment, cell spreading and cell migration in a dose-dependent manner. These inhibitory effects were associated with intracellular depletion of glutathione (GSH). At concentrations of 0.4 mM and 1 mM, arecoline depleted about 26% and 45% of GSH after 2 h incubation. Exposure of cells to arecoline at concentrations lower than 0.4 mM for 2 h showed no significant decrease in either cell viability or intracellular GSH. However, incubation of cells for 24 h in 1 mM are colined decreased the cell numbers to only 35% of those in the untreated control. Arecoline also decreased cell growth and collagen synthesis in a dose-dependent manner. Because of repeated and long-term exposure to arecoline, BQ chewers could be more susceptible to periodontal damage and less responsive to new attachment procedures.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
D
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0904-2512
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
371-5
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8890051-Arecoline,
pubmed-meshheading:8890051-Cell Adhesion,
pubmed-meshheading:8890051-Cell Count,
pubmed-meshheading:8890051-Cell Division,
pubmed-meshheading:8890051-Cell Movement,
pubmed-meshheading:8890051-Cell Survival,
pubmed-meshheading:8890051-Cells, Cultured,
pubmed-meshheading:8890051-Collagen,
pubmed-meshheading:8890051-Disease Susceptibility,
pubmed-meshheading:8890051-Dose-Response Relationship, Drug,
pubmed-meshheading:8890051-Fibroblasts,
pubmed-meshheading:8890051-Gingiva,
pubmed-meshheading:8890051-Glutathione,
pubmed-meshheading:8890051-Humans,
pubmed-meshheading:8890051-Periodontal Diseases
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Inhibition of the migration, attachment, spreading, growth and collagen synthesis of human gingival fibroblasts by arecoline, a major areca alkaloid, in vitro.
|
| pubmed:affiliation |
School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|