Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1996-12-26
pubmed:abstractText
It is important, given the potential use of MIS as an anticancer agent against tumors of Müllerian duct origin, that the search continue to identify binding isoforms of the MIS type II receptor or to identify other factors in the heteromeric complex that might be required for specific binding of this ligand to be observed. With confidence in binding one can use receptor probes to screen patients with ovarian cancer and to identify those that express receptor. This subgroup can then be examined for binding of the MIS ligand and subsequently for antiproliferative response to MIS, in order to preselect candidate patients for receptor-directed MIS treatment. Thus, a once obscure phenomenon observed in the Freemartin has led to the purification and cloning of MIS and the identification of its receptor components, as well as an understanding of their regulation and expression. Elucidation of these molecular events brings us closer to the use of molecules such as MIS in the clinical setting.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0196-3635
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
336-41
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Molecular biology of MIS and its receptors.
pubmed:affiliation
Department of Surgery, Massachusetts General Hospital, Boston 02114, USA.
pubmed:publicationType
Journal Article, Review