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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1997-2-5
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pubmed:abstractText |
Peroxynitrite, formed by reaction of superoxide and nitric oxide, appears to be an important tissue-damaging species generated at sites of inflammation. In this paper, we compare the abilities of several biological antioxidants to protect against peroxynitrite-dependent inactivation of alpha 1-antiproteinase, and to inhibit tyrosine nitration upon addition of peroxynitrite. GSH and ascorbate protected efficiently in both systems. Uric acid inhibited tyrosine nitration but not alpha 1-antiproteinase inactivation. The possibility that ascorbic acid is an important scavenger of reactive nitrogen species in vivo is discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1071-5762
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
275-83
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8889493-Antioxidants,
pubmed-meshheading:8889493-Arthritis, Rheumatoid,
pubmed-meshheading:8889493-Ascorbic Acid,
pubmed-meshheading:8889493-Humans,
pubmed-meshheading:8889493-Lipid Peroxidation,
pubmed-meshheading:8889493-Nitrates,
pubmed-meshheading:8889493-Oxidation-Reduction,
pubmed-meshheading:8889493-Oxidative Stress,
pubmed-meshheading:8889493-Pancreatic Elastase,
pubmed-meshheading:8889493-Synovial Fluid,
pubmed-meshheading:8889493-Tyrosine,
pubmed-meshheading:8889493-alpha 1-Antitrypsin
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pubmed:year |
1996
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pubmed:articleTitle |
Protection against peroxynitrite-dependent tyrosine nitration and alpha 1-antiproteinase inactivation by ascorbic acid. A comparison with other biological antioxidants.
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pubmed:affiliation |
Neurodegenerative Disease Research Centre, King's College, London, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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