Linked Life Data

8887319

Source:http://linkedlifedata.com/resource/pubmed/id/8887319

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1997-3-6
pubmed:abstractText
Receptor protein-tyrosine phosphatase alpha (RPTP alpha) is a transmembrane member of the family of protein-tyrosine phosphatases (PTPs) that has been implicated in neuronal differentiation in vitro. Here we demonstrate that RPTP alpha is differentially expressed during mouse embryogenesis in a spatio-temporal manner. RPTP alpha expression was detectable in 6 days post coitum (dpc) embryos, but not in 7.5 dpc embryos. From 10.5 dpc onwards a striking RPTP alpha expression pattern was observed with elevated levels in the dorsal root ganglia, cranial ganglia and adrenal gland, suggesting that RPTP alpha levels are specifically enhanced in neural crest derivatives. Marked differences between RPTP alpha mRNA and protein levels indicated that RPTP alpha expression is regulated by transcriptional and (post-) translational mechanisms. The expression pattern of RPTP alpha suggests that RPTP alpha may play a role in neural crest cell differentiation in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0925-4773
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
89-101
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Expression of receptor protein-tyrosine phosphatase alpha mRNA and protein during mouse embryogenesis.
pubmed:affiliation
Hubrecht Laboratory, Netherlands Institute for Development Biology, Utrecht, The Netherlands. hertog@hubrecht.nl
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't